Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Lange, Adam, Dr.


  • 10/1997 - 11/2002 Studies of Physics at the Georg-August-University Göttingen
  • 11/2002 - 09/2006 PhD/Postdoctoral studies at the Max Planck Institute for Biophysical Chemistry
  • 10/2003 - 04/2004 Research visit at the National Institutes of Health, Bethesda, Maryland, USA
  • 2006 R. R. Ernst Award of the German Chemical Society
  • 2006 Otto Hahn Medal of the Max Planck Society
  • 10/2006 - 08/2008 Postdoctoral fellow at the Laboratory of Physical Chemistry, ETH Zürich, Switzerland, EMBO long-term fellowship
  • Since 09/2008 Group leader at the Max Planck Institute for Biophysical Chemistry, Emmy Noether fellowship




Major Research Interests

We develop and apply novel solid-state NMR methods for the characterization of biomolecular structure and dynamics. In particular, we are interested in membrane proteins embedded in lipid bilayers. For example, we are studying the voltage-dependent anion channel (VDAC) that is located in the mitochondrial outer membrane and constitutes the major pathway for the transport of ADP, ATP, and other metabolites. Another focus of our research is on the structural characterization of aggregates formed by the proteins tau and alpha-synuclein that are involved in neurodegenerative diseases. In terms of methodology the focus is on new experiments using fast magic-angle spinning with the goal to further improve resolution and sensitivity of solid-state NMR spectroscopy.


Homepage Department/Research Group

http://www.mpibpc.mpg.de/lange



Selected Recent Publications


  • J.-P. Demers, N. G. Sgourakis, R. Gupta, A. Loquet, K. Giller, D. Riedel, B. Laube, M. Kolbe, D. Baker, S. Becker, and A. Lange (2013) The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles. PLOS Pathogens, e1003245
  • V. Daebel, S. Chinnathambi, J. Biernat, M. Schwalbe, B. Habenstein, A. Loquet, E. Akoury, K. Tepper, H. Müller, M. Baldus, C. Griesinger, M. Zweckstetter, E. Mandelkow, V. Vijayan, and A. Lange (2012) β-sheet core of tau paired helical filaments revealed by solid-state NMR. Journal of the American Chemical Society, 134, 13982-13989
  • A. Loquet, N. G. Sgourakis, R. Gupta, K. Giller, D. Riedel, C. Goosmann, C. Griesinger, M. Kolbe, D. Baker, S. Becker, and A. Lange (2012) Atomic model of the type III secretion system needle. Nature, 486, 276-279
  • Loquet, G. Lv, K. Giller, S. Becker, and A. Lange, (2011)13C spin dilution for simplified and complete solid-state NMR resonance assignment of insoluble biological assemblies. Journal of the American Chemical Society, 133, 4722-4725
  • Schneider R, Etzkorn M, Giller K, Daebel V, Eisfeld J, Zweckstetter M, Griesinger C, Becker S, Lange A (2010) The native conformation of the human VDAC1 N terminus, Angewandte Chemie-International Edition, 49, pp. 1882-1885
  • Vijayan V, Demers JP, Biernat J, Mandelkow E, Becker S, Lange A (2009) Lowpower solid-state NMR experiments for resonance assignment under fast magic-angle spinning, ChemPhysChem, 10, 2205-2208
  • Lange A, Scholz I, Manolikas T, Ernst M, Meier BH (2009) Low-power cross polarization in fast magic-angle spinning NMR experiments, Chemical Physics Letters, 468, 100-105
  • Wasmer C*, Lange A*, Van Melckebeke H*, Siemer AB, Riek R, Meier BH (2008) Amyloid fibrils of the HET-s(218-289) prion form a β− solenoid with a triangular hydrophobic core, Science, 319, pp. 1523-1526
  • Lange A, Giller K, Hornig S, Martin-Eauclaire MF, Pongs O, Becker S, Baldus M (2006) Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR, Nature, 440, pp. 959-962