Irniger, Stefan, PD Dr.
- 2005-2009: Interim professorship, Institute of Microbiology, Leibniz-University Hannover
- 2004: Habilitation in Microbiology and Genetics, Georg-August-University Göttingen
- since 1997: Group leader, Institute of Microbiology and Genetics, Georg-August-University Göttingen
- 1993–1996: Postdoctoral research assistant, Research Institute of Molecular Pathology (IMP), Vienna, Austria
- 1992: Dissertation, Institute of Microbiology, Swiss Federal Institute of Technology (ETH), Zürich, Switzerland
- 1983–1987: Studies of Biotechnology, Swiss Federal Institute of Technology (ETH), Zürich, Switzerland
Major Research Interests
Aspergillus strains produce various important secondary metabolites, including antibiotics and mycotoxins such as aflatoxins. Secondary metabolism is coupled to developmental programs and is controlled by external signals.
The focus of our research projects is to get insights into signal transduction mechanisms regulating development and secondary metabolism in the model organism Aspergillus nidulans.
Homepage Department/Research Group
Selected Recent Publications
Irniger S (2011). The Ime2 protein kinase family in fungi: more duties than just meiosis. Mol Microbiol. 80(1): 1-13
Sari F, Heinrich M, Meyer W, Braus GH, Irniger S (2008) The C-terminal region of the meiosis-specific protein kinase Ime2 mediates protein instability and is required for normal spore formation in budding yeast. J. Mol. Biol.378:31-43
Garrenton LS, Braunwarth A, Irniger S, Hurt E, Künzler M, Thorner J (2009) Nucleus-specific and cell cycle-regulated degradation of mitogenactivated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol. Cell. Biol. 29:582-601.
Bayram Ö, Sari F, Braus GH, Irniger S (2009) The protein kinase ImeB is required for light-mediated inhibition of sexual development and for 7 mycotoxin production in Aspergillus nidulans. Mol. Microbiology, 71:1278-1295
Kuczera T, Bayram Ö, Sari F, Braus GH, Irniger S (2010) Dissection of mitotic functions of the yeast cyclin Clb2. Cell Cycle 9: 2609-2617
Sarikaya Bayram Ö, Bayram O, Valerius O, Park HS, Irniger S, Gerke J, Ni M, Han KH, Yu JH, Braus GH (2010) LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity. PLOS Genetics, e1001226
Kuczera T, Stilling RM, Hsia HE, Bahari-Javan S, Irniger S, Nasmyth K, Sananbenesi F, Fischer A (2011) The anaphase promoting complex is required for memory function in mice. Learning and Memory, 18: 49-57