Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Wittenmayer, Nina, Dr.*

Wittenmayer, Nina, Dr.

  • 2003, Dr. rer nat (Biology), Technical University Braunschweig
  • 2004-2010, Postdoctoral research with T. Dresbach at the University of Heidelberg, Institute for Anatomy and Cell Biology (Dept. Prof. Dr. J. Kirsch)
  • since 2010 postdoctoral fellow at the Center for Anatomy, University Göttingen (Prof. T. Dresbach)
  • since 2011 Heidenreich von Siebold Habilitation Programm

  • Major Research Interests

    The focus of our lab is the study of the molecular basis of synaptogenesis and the development of synapses. Our primary interests lie in understanding the regulation of presynaptic formation and maturation under the control of transsynaptic signalling, for instance how postsynaptic molecules mediate structural and functional changes of presynaptic nerve terminals. We use conventional fluorescence and high resolution microscopy in combination with live cell imaging to analyse changes of the synaptic molecular architecture and to measure presynaptic function, including exocytosis and endocytosis. For this purpose we use chemical, molecular and genetic tools to investigate the role of specific proteins and molecules such as active zone or postsynaptic density proteins or neurotrophic factors. We concentrate on specific brain regions (cortex, hippocampus, amygdala) to generate a comprehensive picture about synaptic function of the brain and attempt to provide new information concerning the question: how do nerve terminals work properly?

    Homepage Department/Research Group


    Selected Recent Publications

  • Murk K*, Wittenmayer N*, Michaelsen K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M (2012) Neuronal Profilin isoforms are addressed by different signalling pathways. PLoS One. 2012;7(3):e34167. * equal contribution
  • Stan A, Pielarski N, Brigadski T, Wittenmayer N, Fedorchenco O, Gohla A, Lessman V, Dresbach T, Gottmann K (2010) Essential cooperation of N-Cadherin and Neuroligin1 in the transsynaptic control of vesicle accumulation. Proc Natl Acad Sci USA 107:11116-21
  • Wittenmayer N, Korber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc Natl Acad Sci USA106:13564-13569
  • Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED (2006) Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. J Biol Chem 281:6038-6047
  • Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S, Jockusch BM (2004) Tumor suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell 15(4):1600-8
  • Wittenmayer N, Rothkegel M, Jockusch BM, Schlüter K (2000) Functional characterisation of green fluorescent protein-profilin fusion proteins. Eur J Biochem 267(16):5247-56