Hallermann, Stefan, PD Dr.
Group Leader High-frequency Signaling
- 2000 Diploma in physics, Technical University Munich
- 2005 MD, Albert-Ludwigs-University Freiburg
- 2011 Habilitation (Physiology), University of Leipzig
- since 2011 Group leader at the European Neuroscience Institute Göttingen
Major Research Interests
Evolutionary pressure has led to the development of remarkably precise and rapid information processing in our central nervous system. Visual and vestibular signals, for example, can be processed with high precision within split seconds. However, most of the underlying cellular mechanisms remain poorly understood.
Our group aims to understand the mechanisms of high-frequency signaling on various levels, ranging from single molecules to neuronal networks. We use cutting-edge electrophysiological, optical, genetic and computational methods, such as direct whole-cell patch-clamp recordings from presynaptic nerve terminals, capacitance measurements and two-photon calcium imaging. We are also driven by the chance that basic neuroscience research will help advance therapeutic possibilities in psychiatry and neurology.
Homepage Department/Research Group
Selected Recent Publications
Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012) State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci 15:1007-1014
Weyhersmüller A*, Hallermann S*, Wagner N, Eilers J (2011) Rapid active zone remodeling during synaptic plasticity. J Neurosci 31:6041-6052
Hallermann S, Fejtova A, Schmidt H, Weyhersmüller A, Silver RA, Gundelfinger ED, Eilers J (2010) Bassoon speeds vesicle reloading at a central excitatory synapse. Neuron 68: 710-723
Hallermann S*, Kittel RJ*, Wichmann C*, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M (2010) Naked dense bodies provoke depression. J Neurosci 30:14340-14345
Hallermann S, Heckmann M, Kittel RJ (2010) Mechanisms of short-term plasticity at neuromuscular active zones of Drosophila. HFSP J 4:72-84
Schmid A*, Hallermann S*, Kittel RJ, Khorramshahi O, Frölich AM, Quentin C, Rasse TM, Mertel S, Heckmann M, Sigrist SJ (2008) Activity-dependent site-specific changes of glutamate receptor composition in vivo. Nat Neurosci 11:659-666
Kole MH*, Hallermann S*, Stuart G. (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution and impact on action potential output. J Neurosci 26: 1677-1687
Hallermann S, Heckmann S, Dudel J, Heckmann M (2005) Short openings in high resolution single channel recordings of mouse nicotinic receptors. J Physiol 563: 645-662
Hallermann S, Pawlu C, Jonas P, Heckmann M (2003) A large pool of releasable vesicles in a cortical glutamatergic synapse. Proc Natl Acad Sci U S A 100: 8975-8980