Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Karlovsky, Petr, Prof. Dr.

Professor of Molecular Phytopathology and Mycotoxin Research


  • Professor of Molecular Phytopathology and Mycotoxin Research at Georg-August-University, Göttingen, Germany (since 2007)
  • Professor of Molecular Phytopathology at Georg-August-University, Göttingen, Germany (2002-2006)
  • Research Manager, DuPont/Pioneer Hi-Bread, Johnston (IA) and Newark (DE), USA (2000-2001)
  • Research Associate, University of Hohenheim, Stuttgart, Germany (1994-1999)
  • Visiting Professor at the University of Connecticut, Storrs, USA (1993)
  • Research Fellow at Georg-August-University, Göttingen, Germany (1991-1993)
  • Visiting Scientist at Gesellschaft für Strahlen- und Umweltforschung, Göttingen, Germany (1986-1990)
  • PhD in Molecular Genetics, Institute of Biophysics, Brno, Czech Republic (1986)
  • Diploma in Biochemistry, J-E-Purkynje-University, Brno, Czech Republic (1981)




Major Research Interests

Why do secondary metabolites exist in Nature, what biological roles they play? These questions motivate our research. Thousands of new secondary metabolites are being discovered each year by chemists and pharmaceutical companies but hardly anything is known about their functions. Strong and diverse biological activities exerted by secondary metabolites have been attracting extensive applied research. Fungal metabolites toxic to animals, called mycotoxins, threaten the health of consumers and farm animals when ingested with food and feed. Microbial and plant metabolites inhibiting the growth of pathogens or of cancer cells serve as lead structures for drugs and pesticides. Secondary metabolites with antioxidative and chemoprotective activities as well as those contributing to the taste, aroma and color of food are important quality factors of food commodities. Our lab addresses selected fundamental and applied questions related to secondary metabolites with focus on the following topics:
- Chemical interaction of fungi with other fungi, plants and arthropods
- Relationship between genomic and metabolic diversity
- Biological function of plant root exudates
- Enzymatic detoxification of mycotoxins




Homepage Department/Research Group

http://www.fungal-toxins.uni-goettingen.de/



Selected Recent Publications


  • Karlovsky P, Suman M, Berthiller F, De Meester J, Eisenbrand G, Perrin I, Oswald IP, Speijers G, Chiodini A, Recker T, Dussort P (2016): Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Research, epub before print: DOI 10.1007/s12550-016-0257-7
  • Chatterjee S, Kuang Y, Splivallo R, Chatterjee P, Karlovsky P (2016) Interactions among filamentous fungi Aspergillus niger, Fusarium verticillioides and Clonostachys rosea: fungal biomass, diversity of secreted metabolites and fumonisin production. BMC Microbiology 16/83 (13 pp)
  • Horbach R, Becher R, Deising H, Karlovsky P (2015): Method for biosynthesis of specific isotope-marked secondary metabolites. Patent Application WO/2015/003679, PCT/DE2014/000343
  • Splivallo R, Deveau A, Valdez N, Kirchhoff N, Frey-Klett P, Karlovsky P (2014): Bacteria associated with truffle fruiting bodies contribute to truffle aroma. Env Microbiol 17:2647-2660
  • Splivallo R, Valdez N, Kirchhoff N, Ona MC, Schmidt JP, Feussner I, Karlovsky P (2012): Intraspecific genotypic variability determines concentrations of key truffle volatiles. New Phytologist 194:823-835
  • Nutz S, Döll K, Karlovsky P (2011): Determination of the LOQ in real-time PCR by receiver operating characteristic curve analysis: application to qPCR assays for Fusarium verticillioides and F. proliferatum. Analytical and Bioanalytical Chemistry 401:717-726