Fischle, Wolfgang, Dr.
Group Leader at the MPI for Biophysical Chemistry
- Dr. rer. nat. (PhD), University of Tübingen, Germany, 2001
- Graduate Research Fellow, The J. David Gladstone Institute (UCSF), San Francisco, CA, USA, 1997-2001
- Postdoctoral Fellow, The Rockefeller University, New York, NY, USA, 2001-2005
- Damon Runyon Cancer Research Fellow, 2002-2005
- Head of the Chromatin Biochemistry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, since 2006
- Professor of Cellular and Molecular Biology, KAUST, Thuwal, KSA since 2015
Major Research Interests
To sustain life in different environments cells and organisms must adjust to different conditions and external cues. In contrast to immediate and mostly transient responses to short-term stimuli, processes of long-term adaptation require lasting changes in gene expression patterns. Such epigenetic changes are controlled on the level of chromatin, the packaging form of eukaryotic genomes. Here, different DNA and histone modifications are associated with distinct functional states of chromatin.
Overall, our research aims to gain detailed, fundamental understanding of the processes that read and translate patterns of chromatin marks for mediating biological outcomes. Currently, we are tackling two main questions. A) How do histone modifications in conjunction with DNA methylation establish seemingly stable chromatin structures in response to internal and external cues? B) How do small cellular metabolites and signaling molecules tune the readout of chromatin marks? To address these problems we are constantly expanding our highly interdisciplinary approaches. These include advancing technologies for establishing and analyzing complex chromatin systems in vitro (biochemistry and biophysics), molecular and cellular biology for studying essential chromatin components and global analysis of modules of epigenetic regulation.
We strongly believe that by understanding the essential molecular control mechanisms of chromatin regulation we will ultimately be able to develop strategies for intervention of major diseases.
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