Stoykova, Anastassia, Prof. Dr.
Adj. Professor of Developmental Biology
Major Research Interests
The research interest of the group is focused on molecular mechanisms for patterning and neurogenesis of developing and adult brain, with an emphasis on the mammalian corticogenesis. The neocortex is a mammal-specific region of the cerebrum in which billion of neurons are distributed in six layers and multiple functional domains, acting as an integrative and executive center. The complex organization of the neocortex arises from a limited number of neural stem cells through precisely controlled phases of cell proliferation, differentiation, migration and death. Particularly we are interested to understand genetic mechanisms, controlled by the evolutionary conserved transcription factors Pax6 in specification of neuronal subtype identity, layer, and area formation during cortical development. Another task is addressing the control of cell differentiation in developing cortex by the chromatin remodeling complex mSWI/SNF. Recent projects of the group include the role of microRNAs on the progression of brain tumors, and molecular mechanisms involved in generation, maintenance and function of progenitor/stem cells in the neurogenic niches of the adult brain, an important issue in helping to devise replacement strategies for eventual brain repair. Using the mouse as a model, we are applying a range of cell- and molecular biological, biochemical, and genetic methods and approaches for manipulation of gene activity in transgenic mice and after somatic electroporation in developing mouse brain.
Homepage Department/Research Group:
Selected Recent Publications
Mol Neurobiology (doi:10.1007/sl2035-016-9948-5).
controls centriole maturation in cortical progenitors through Odf2.
Cellular and Molecular Life Sciences 72 (9): 1795-1809
Stoykova A (2014) Scratch2 modulates neurogenesis and cell migration
through antagonism of bHLH proteins in the developing neocortex.
Cerebral Cortex 24 (3): 754-772
Stoykova A (2013) Chromatin regulation by BAF170 controls cerebral
cortical size and thickness. Developmental Cell 25 (3): 256-269
(2013) Sensory cortex limits cortical maps and drives top-down
plasticity in thalamocortical circuits. Nature Neuroscience 16 (8): 1060--
Molnar Z, Davidoff MS, Stoykova A (2009) Selective cortical layering
abnormalities and behavioral deficits in cortex-specific Pax6 knock-out
mice. Journal of Neuroscience 29 (26): 8335-8349