Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Stoykova, Anastassia, Prof. Dr.

Adj. Professor of Developmental Biology

  • since 2010 Adj. Professor at the University of Göttingen
  • since 2008 Independent Research Group Leader MPI-bpc (W2, MPG Minerva Program)
  • 2002 - 2008 Research Group Leader, Dept. Mol Cell Biol, MPIPBC, Göttingen
  • 1998 Habilitation (developmental biology), Faculty of Medicine, University Göttingen
  • 1991 - 2002 Senior Research Scientist, Max Planck Institute for Biophysical Chemistry, Dept. Molecular Cell Biology, Göttingen
  • 1989 - 1991 Assistant Research Professor, Inst. Mol. Biol., Bulg. Acad. Sci., Sofia
  • 1989 Habilitation (neurochemistry), Sofia
  • 1987 PhD, Institute Molecular Biology, Bulg. Acad. Sci., Sofia
  • 1973 - 1988 Research Associate, Bulgarian Academy of Sciences, Sofia
  • M.D., 1972, Bulgarian Medical Academy

  • Major Research Interests

    The research interest of the group is focused on molecular mechanisms for patterning and neurogenesis of developing and adult brain, with an emphasis on the mammalian corticogenesis. The neocortex is a mammal-specific region of the cerebrum in which billion of neurons are distributed in six layers and multiple functional domains, acting as an integrative and executive center. The complex organization of the neocortex arises from a limited number of neural stem cells through precisely controlled phases of cell proliferation, differentiation, migration and death. Particularly we are interested to understand genetic mechanisms, controlled by the evolutionary conserved transcription factors Pax6 in specification of neuronal subtype identity, layer, and area formation during cortical development. Another task is addressing the control of cell differentiation in developing cortex by the chromatin remodeling complex mSWI/SNF. Recent projects of the group include the role of microRNAs on the progression of brain tumors, and molecular mechanisms involved in generation, maintenance and function of progenitor/stem cells in the neurogenic niches of the adult brain, an important issue in helping to devise replacement strategies for eventual brain repair. Using the mouse as a model, we are applying a range of cell- and molecular biological, biochemical, and genetic methods and approaches for manipulation of gene activity in transgenic mice and after somatic electroporation in developing mouse brain.

    Homepage Department/Research Group:


    Selected Recent Publications

  • Tuoc T, Dere E, Radyushkin R, Pham L, Nguen H, Tonchev A, Ronnenberg A, Shi Y, Steiger J, Eherenreich H, Stoykova A (2016) Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation and learning.
    Mol Neurobiology (doi:10.1007/sl2035-016-9948-5).
  • Tylkowski MA, Yang K, Hoyer-Fender S, Stoykova A (2015) Pax6
    controls centriole maturation in cortical progenitors through Odf2.
    Cellular and Molecular Life Sciences 72 (9): 1795-1809
  • Paul V, Tonchev AB, Henningfeld KA, Pavlakis E, Rust B, Pieler T,
    Stoykova A (2014) Scratch2 modulates neurogenesis and cell migration
    through antagonism of bHLH proteins in the developing neocortex.
    Cerebral Cortex 24 (3): 754-772
  • Tuoc TC, Boretius S, Sansom SN, Pitulescu M, Frahm J, Livesey FJ,
    Stoykova A (2013) Chromatin regulation by BAF170 controls cerebral
    cortical size and thickness. Developmental Cell 25 (3): 256-269
  • Zembrzycki A, Chou SJ, Ashery-Padan R, Stoykova A, O'Leary DDM
    (2013) Sensory cortex limits cortical maps and drives top-down
    plasticity in thalamocortical circuits. Nature Neuroscience 16 (8): 1060--
  • Tuoc TC, Radyushkin K, Tonchev AB, Pinon MC, Ashery-Padan R,
    Molnar Z, Davidoff MS, Stoykova A (2009) Selective cortical layering
    abnormalities and behavioral deficits in cortex-specific Pax6 knock-out
    mice. Journal of Neuroscience 29 (26): 8335-8349