Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Flügge, Gabriele, Prof. Dr.

Apl. Professor, Experimental Neuroscience


  • Dr. rer. nat., University of Munich, 1979
  • Senior Scientist, Clinical Neurobiology Laboratory at the German Primate Center



Major Research Interests

In humans, stressful or traumatic life events such as death of a close relative often represent a strong psychological load that may induce psychopathologies such as depression. The central nervous mechanisms that lead to such diseases are still not clear. We therefore investigate processes that occur in the course of chronic psychosocial stress in the brains of animals that show similar symptoms as depressed patients. Using molecular techniques, we identify central nervous genes that are regulated by stress; quantitative real time PCR, in situ hybridization and immunocytochemistry serve to localize changes in neurotransmitter systems, receptors, transporters and other molecules in distinct neurons of the brain. Similar tools are used to clarify the mechanisms that underlie the beneficial effects of antidepressant drugs. In conjunction with behavioral studies we are able to find molecular factors that play a role in central nervous processes underlying depression.


Homepage Department/Research Group

http://www.cnl-dpz.de/start.htm



Selected Recent Publications


  • Hu W, Zhang M, Czéh B, Flügge G, Zhang W (2010) Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network. Neuropsychopharmacology 35: 1693-1707
  • Perez-Cruz C, Simon M, Flügge G, Fuchs E, Czéh B (2009) Diurnal rhythm and stress regulate dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortex. Behav Brain Research (2009) 205: 406-413
  • Herzog CJ, Czéh B, Corbach S, Wuttke W, Schulte-Herbrüggen O, Hellweg R, Flügge G, Fuchs E (2009) Chronic social instability stress in female rats: A potential animal model for female depression. Neuroscience 159: 982-992
  • Perez-Cruz C, Simon M, Czéh B, Flügge G, Fuchs E (2009) Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes. Eur J Neurosci 29: 738-747
  • Cooper B, Fuchs E, Flügge G (2009) Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress. PLoS ONE 4(1):e3659
  • Czéh B, Perez-Cruz C, Fuchs E, Flügge G (2008) Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: does hemisphere location matter? Behav Brain Res 190: 1-13
  • Cooper B, Werner HB, Flügge G (2008) Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Res 1197:1-12
  • Abumaria N, Ribic A, Anacker C, Fuchs E, Flügge G (2008) Stress Upregulates TPH1 but not TPH2 mRNA in the Rat Dorsal Raphe Nucleus: Identification of Two TPH2 mRNA Splice Variants. Cell Mol Neurobiol 28(3):331-42
  • Rygula R, Abumaria N, Havemann-Reinecke U, Rüther E, Hiemke C, Zernig G, Fuchs E, Flügge G (2008) Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam. Behav Pharmacol 19: 183-196
  • Abumaria N, Rygula R, Hiemke C, Fuchs E, Havemann-Reinecke U, Ruther E, Flügge G (2007) Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat. Eur Neuropsychopharmacol 17: 417-429