Veranstaltung
An unmapped toxic mechanism in neurodegeneration-Inhibition of protein folding chaperones by neurotoxic dipeptide repeats| Titel der Veranstaltung | An unmapped toxic mechanism in neurodegeneration-Inhibition of protein folding chaperones by neurotoxic dipeptide repeats |
| Reihe | campus seminar |
| Veranstalter | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Referent/in | Maria Babu |
| Einrichtung Referent/in | Group for Structure Determination of Proteins Using NMR |
| Veranstaltungsart | Seminar |
| Kategorie | Forschung |
| Anmeldung erforderlich | Nein |
| Beschreibung | Dipeptide repeat proteins are aberrantly expressed in the brain of ALS/FTD patients due to a mutation in the C9orf72 gene. The neurotoxic mechanism of these dipeptide repeats is associated to their anomalous interaction with cellular proteins, thus interfering with several physiological pathways. We explored a new toxic mechanism of dipeptide repeats that is linked to the inhibition of prolyl isomerases (a class of protein folding chaperones) that disrupt protein homeostasis. |
| Zeit | Beginn: 24.11.2021, 11:00 Uhr Ende: 24.11.2021 , 12:00 Uhr |
| Ort |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Manfred Eigen Hall & Online |
| Kontakt |
Stefan Glöggler stefan.gloeggler@mpibpc.mpg.de |