Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Griesinger, Christian, Prof. Dr.

Professor, Director at the Max Planck Institute for Biophysical Chemistry, Göttingen


  • Dr. phil. nat. University of Frankfurt (1986, Prof. Dr. H. Kessler)
  • Postdoctoral Fellow at Lab. for Physical Chemistry, ETH Zürich (1986 - 1989, Prof. Dr. R. R. Ernst)
  • Full Professor for Organic Chemistry at the University of Frankfurt (1990 - 2000)
  • Appointed as Director at the Max Planck Institute for Biophysical Chemistry (1998)




Major Research Interests

In the department, we develop NMR spectroscopic methods and apply them to the investigation of water soluble and membrane proteins, nucleic acids and their complexes as well as drug/target complexes. We are specifically focussing on the dynamics of biomolecules.Structural biology projects are performed in the context of signal transduction, ion channels, cytoskeletal proteins, enzymes and drug/target complexes using NMR as well as X-ray crystallography to characterize structure and dynamics. An applied project is the investigation of proteins involved in neurodegenerative diseases that are studied in the context of the CNMPB and involve NMR and other biophysical methods as well as chemical synthesis. Methods developments are aimed at pushing the limits of sensitivity for NMR spectroscopic detection (e.g. DNP), developing the measurement of structurally and dynamically relevant parameters, establishing methods to describe structural ensembles for folded and intrinsically disordered proteins. For solid state NMR investigations, pulse sequences that allow structure determination of uniformly labelled membrane proteins as well as oligomers and fibrils formed from proteins involved in neurodegenerative diseases have been successfully developed.


Homepage Department/Research Group

http://medusa.nmr.mpibpc.mpg.de/



Selected Recent Publications


  • Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A (2013) “Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease”, Acta Neuropathol 2013, 125 (6) 795-813
  • Honndorf V, Coudevylle N, Laufer S, Becker S, Griesinger C*, Habeck M* (2012) Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38a MAP kinase complex in solution. Angew Chem Int Ed, 51:2359-2362
  • Ban D, Funk M, Gulich R, Egger D, Sabo TM, Walter KFA, Bryn Fenwick R, Giller K, Pichierri F, de Groot BL, Lange OF, Grubmüller H, Salvatella X, Wolf M, Loidl A, Kree R, Becker S, Lakomek NA, Lee D, Lunkenheimer P, Griesinger C (2011) Kinetics of Conformational Sampling in Ubiquitin. Angew Chem Int Ed, DOI:10.1002/anie.201105086
  • Rodriguez-Castaneda F, Maestre-Martinez M. Coudevylle N, Dimova K, Junge H, Lipstein N, Lee D, Becker S, Brose N, Jahn O, Carlomagno T, Griesinger C (2010) Modular Architecture of Munc13/calmodulin complexes: dual recognition by Ca2+ and possible function in short-term synaptic plasticity. EMBO J 29, 680-91
  • Kumar A, Heise H,. Blommers MJJJ, Krastel P, Schmitt E, Petersen F, Jeganathan S, Mandelkow EM, Carlomagno T, Griesinger C, Baldus M (2010) Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid State NMRSpectroscopy. Angew Chem Int Ed 49: 7666-69
  • Lee D, Walter KFA, Brückner AK, Hilty C, Becker S, Griesinger C (2008) Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy, J Am Chem Soc 130:13822-3
  • Lange O, Lakomek NA,. Farès C, Schroeder GF, Walter K, Becker S, Meiler J, Grubmueller H, Griesinger C, de Groot BL (2008) Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science 320:1471-1475
  • Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, Zeth K (2008) Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci USA 105:15370-15375