Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Dr. Hiroshi Kawabe


  • 2000-2002 Postdoctoral Fellow, Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine, Faculty of Medicine, Osaka, Japan (with Professor Yoshimi Takai)
  • 2002-2008 Postdoctoral Fellow, Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany (with Professor Nils Brose)
  • 2008-2016 Project Group Leader, Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany
  • since 2016 Research Group Leader, Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany




Major Research Interests


  • Neuronal protein homeostasis


  • Selected Recent Publications


    • Altas, B.*, Jahn, O., and Kawabe, H.* (2017) Biochemical Purification of Binding Partners of Synaptic Scaffold Proteins. Methods Mol. Biol. (accepted) *Co-corresponding authors
    • Ambrozkiewicz, M. C.* and Kawabe, H.* (2015) HECT-Type E3 Ubiquitin Ligases in Nerve Cell Development and Synapse Physiology. FEBS Letters 589, 1635-1643 *Co-corresponding authors
    • Hsia, H. E., Kumar, R., Luca, R., Takeda, M., Courchet, J., Nakashima, J., Wu, S., Goebbels, S., An, W., Eickhol,t B., Polleux, F., Rotin, D., Wu, H., Rossner, M., Bagni, C., Rhee, J. S., Brose, N., and Kawabe, H.* (2014) The Ubiquitin E3 Ligase Nedd4-1 Acts as a Downstream Target of PI3K/PTEN-mTORC1 Signaling to Promote Neurite Growth. Proc. Natl. Acad. Sci. U. S. A. 111, 13205-13210 *Corresponding author
    • Kimura, T.*, Kawabe, Jiang, C., Zhang, W., Xiang, Y. Y., Lu, C., Salter, M. W., Brose, N., Lu, W. Y., and Rotin, D. (2011) Deletion of the Ubiquitin Ligase Nedd4L in Lung Epithelia Causes Cystic Fibrosis-Like Disease. Proc. Natl. Acad. Sci. U. S. A. 108, 3216-3221. *Equal contribution
    • Kawabe, H.*, Neeb, A., Dimova, K., Young, S. M. Jr., Takeda, M., Katsurabayashi, S., Mitkovski, M., Malakhova, O. A., Zhang, D. E., Umikawa, M., Kariya, K., Goebbels, S., Nave, K. A., Rosenmund, C., Jahn, O., Rhee, J. S., and Brose, N.* (2010) Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development. Neuron 65, 358-372. *Co-corresponding authors