Schlüter, Oliver, Dr. Dr.
- M.D. Ph.D. with Thomas C. Südhof at the Max-Planck-Institute for Experimental Medicine in Göttingen (Germany), 1995 - 2001
- Dr. rer. nat. (PhD) 2000, University of Hannover
- Dr. med. (Medical thesis), University of Göttingen
- Postdoc with Robert C. Malenka at Stanford University Medical Center (USA), 2002 - 2006
- Independent group leader (Emmy-Noether/DFG) at the European Neuroscience Institute Göttingen (ENI-G), since 2006
Major Research Interests
Activity-dependent modulations of synaptic transmission are important mechanisms of information processing and storage in neuronal circuits. A variety of related but mechanistically distinct forms of synaptic plasticity have been described in in vitro preparations of brain slices.
A major goal of my laboratory is to elucidate the underlying molecular events, leading to and regulating changes in synaptic efficacy. Newly developed techniques of molecular replacement, using mouse genetics and/or viral-mediated gene transfer allow us to manipulate the molecular composition of single neurons in a spatial and temporal controlled manner.
In particular, we are able to investigate the effects of heterologously expressed proteins on the background of wild-type neurons, or neurons, in which the endogenous protein expression is diminished. We combine this technique with simultaneous dual whole cell patch clamp recordings from rodent brain slices to monitor changes in synaptic efficacy in the manipulated cell in comparison to the neighboring control cell.
Knowledge gained from the understanding of molecular mechanisms of synaptic transmission and plasticity will ultimately provide important clues for the function of neuronal ircuits and potentially the functioning of the brain.
Homepage Department/Research Group
Selected Recent Publications
- Bonnet SA*, Akad DS*, Samaddar T, Liu Y, Huang X, Dong Y, Schlüter OM# (2013) Synaptic state-dependent functional interplay between Postsynaptic Density-95 and Synapse-associated Protein 102. J Neurosci 33(33), 13398-409.
- Suska A*, Lee BR, Huang YH, Dong Y#, Schlüter OM# (2013). Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine. Proc Ntl Acad Sci USA 110(2), 713-8.
- Brown TE, Lee BR, Mu P, Ferguson D, Dietz D, Ohnishi YN, Lin Y, Suska A, Ishikawa M, Huang YH, Shen H, Kalivas PW, Sorg BA, Zukin RS, Nestler EJ, Dong Y, Schlüter OM (2011) A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci 31, 8163-74.
- Xu* W, Schlüter* OM, Steiner P, Czervionke BL, Sabatini B, Malenka RC (2008) Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 57, 248-62.
- Schlüter* OM, Xu* W, Malenka RC (2006) Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function. Neuron 51, 99-111.
- Schlüter OM, Basu J, Südhof TC, Rosenmund C (2006) Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci 26, 1239-46.
- Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Südhof TC (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123, 383-96