Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Zweckstetter, Markus, Prof. Dr.


  • 1990 - 1996 Studies at the Ludwig Maximilians University of Munich, Degree: Diploma in Physics (passed with distinction)
  • 1993 - 1994 Studies at the University of Edinburgh, Scotland; Physics and Russian
  • 1996 - 1998 PhD project with Dr. Tad Holak, Max-Planck-Institute for Biochemistry, Martinsried
  • 1998 Degree Dr. rer. nat., Technical University of Munich
  • 1998 - 1999 Postdoctoral Fellow at the Max-Planck-Institute for Biochemistry (Dr. Tad Holak)
  • 1999 - 2001 Postdoctoral Fellow at the National Institutes of Health, Bethesda, USA (group of Dr. A. Bax)
  • since 2001 Head of the senior research group "Structure determination of proteins using NMR" at the Max Planck Institute for Biophysical Chemistry, Göttingen
  • 2001-2006 Head of Emmy Noether group at the Max Planck Institute for Biophysical Chemistry, Göttingen
  • 2007-2012 Head of Heisenberg group at the Max Planck Institute for Biophysical Chemistry, Göttingen
  • since 2008 Honorary Professor, University of Göttingen
  • Since 2012 Head of the senior research group "Structural Biology in Dementia" at the German Center for Neurodegenerative Diseases (DZNE), Göttingen
  • since 2012 Professor at the University Medical School, University of Göttingen, Göttingen



Major Research Interests

The goal of our research is to push NMR spectroscopy into new research areas and to provide insights at the molecular level into the factors that are responsible for the neurotoxicity of the proteins alpha-synuclein, Tau and Amyloid-beta peptide during the course of Parkinson’s and Alzheimer’s disease. In addition, we strive to obtain structure-function relationships for integral membrane proteins, such as the human voltage dependent anion channel.


Homepage Department/Research Group

http://www.mpibpc.mpg.de/zweckstetter

http://www.dzne.de/zweckstetter


Selected Recent Publications


  • Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M.>/p> Science. 2014 Mar 21;343(6177):1363-6. doi: 10.1126/science.1248725

  • Hsp90-tau complex reveals molecular basis for specificity in chaperone action. Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Cell. 2014 Feb 27;156(5):963-74

  • ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro T, Looger L, Bähr M, Zweckstetter M, Kügler S. Ann Neurol. 2013 Mar 28. doi: 10.1002/ana.23905. [Epub ahead of print]

  • Cold denaturation of a protein dimer monitored at atomic resolution. Jaremko, M., Jaremko, L., Kim, H.-Y., Cho, M.-K., Schwieters, C. D., Giller, K., Becker, S., Zweckstetter, M. Nat. Chem. Biol. 2013, DOI 10.1038/NChemBio .1181.

  • Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation. Akoury, E., Pickhardt, M., Gajda, M., Biernat, J., Mandelkow, E., Zweckstetter, M. Angew. Chem. Int. Ed. 2013, DOI 10.1002/anie.20120829.

  • Functional dynamics in the voltage-dependent anion channel. Villinger, S., Briones, R., Giller, K., Zachariae, U., Lange, A., de Groot, B. L., Griesinger, C., Becker, S., Zweckstetter, M. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 22546-22551.

  • Structural polymorphism of 441-residue tau at single residue resolution. Mukrasch, M. D., Bibow, S., Korukottu, J., Jeganathan, S., Biernat, J., Griesinger, C., Mandelkow, E., Zweckstetter, M. PLoS Biol. 2009, 7, e34.

  • Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. Karpinar, D.P., Balija, M.B., Kügler, S., Opazo, F., Rezaei-Ghaleh, N., Wender, N., Kim, H.Y., Taschenberger, G., Falkenburger, B.H., Heise, H., Kumar, A., Riedel, D., Fichtner, L., Voigt, A., Braus, G.H., Giller, K., Becker, S., Herzig, A., Baldus, M., Jäckle, H., Eimer, S., Schulz, J.B., Griesinger, C., Zweckstetter, M. EMBO J. 2009, 28, 3256-3268

  • Structure of the human voltage-dependent anion channel. Bayrhuber, M., Meins, T., Habeck, M., Becker, S., Giller, K., Villinger, S., Vonrhein, C., Griesinger, C., Zweckstetter, M., Zeth, K. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 15370-15375.

  • Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Bertoncini, C. W., Jung, Y. S., Fernandez, C. O., Hoyer, W., Griesinger, C., Jovin, T. M., Zweckstetter, M. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 1430-1435.