Bringmann, Henrik, Dr.
Max Planck Research Group Leader Max Planck Research Group Leader since 2009
Postdoctoral fellow at the Laboratory of Molecular Biology, Cambridge, UK
PhD Max Planck Institute for Cell Biology and Genetics, Dresden
Major Research Interests
Sleep states occur in the life of every animal studied. While the function of waking is obvious, the function of sleep is unknown. Sleep has been suggested a restorative function in the nervous system. Our lab is trying to understand the function and regulation of sleep by studying different model organisms. We have started our studies by looking at sleep in the larva of the nematode Caenorhabditis elegans, and are also working with mice.
We are combining behavioral assays with genetics and functional imaging. We recently found a single sleep-inducing neuron in C. elegans that is homologous to mammalian sleep neurons. This highly simplified sleep-inducing system in a tractable genetic model provides a great starting point to understand the regulation of sleep and to manipulate sleep in order to study the function of sleep.
Homepage Department / Research Group
Selected Recent Publications
Turek M, Besseling J, Bringmann H (2015) Agarose microchambers for long-term calcium imaging of Caenorhabditis elegans. J Vis Exp Jun 24;(100):e52742
Turek M, Lewandrowski IL, Bringmann H (2013) An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C.
elegans. Current Biology 23 (22): 2215-2223
Schwarz, J.; Lewandrowski, I. L.; Bringmann, H.:
Reduced activity of a sensory neuron during a sleep-like state in Caenorhabditis elegans. Curr. Biol. 21 (24), R983-R984 (2011)
Redemann, S.; Schloissnig, S.; Ernst, S.; Pozniakowsky, A.; Ayloo, S.; Hyman, A. A.; Bringmann, H.:
Codon adaptation-based control of protein expression in C. elegans. Nature Methods 8 250-252 (2011)