Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Rossner, Moritz, PD Dr. #

  • 1998 PhD, Center of Molecular Biology Heidelberg (ZMBH), University of Heidelberg
  • 2000 Project Leader, Axaron Bioscience AG, Heidelberg
  • 2003 Group Leader, Max-Planck-Institute of Experimental Medicine, Göttingen
  • Professor Molecular and Behavioral Neurobiology, Dep. of Psychiatry, LMU Munich

Major Research Interests

Our research interest is directed towards the generation and analysis of transgenic mouse mutants in order to understand individual gene functions in the adult brain. Towards this goal, we employ mouse genetics, molecular/biochemical and behavioral techniques. Our current interest focuses on basic-helix-loop-helix (bHLH) transcription factors. Several loss- and gain-of-function mouse mutants of the bHLH family that we and others have analyzed display behavioral alterations frequently also observed in psychiatric diseases. Among these are alterations of the sleep-wake or circadian behavior, altered cognitive performances and disturbed environmental adaptations to time shifts (jet-lag) or social stress. At the molecular level, we find several signaling pathways to be deregulated that likely provide a mechanistic link between disturbed environmental adaptations and deregulated gene expression seen in bHLH mouse mutants. To study cellular signaling upstream of gene expression, we have developed a series of genetically encoded biosensors that can be analyzed with standard fluorescent or luminescent reporter proteins but also with libraries of molecular barcodes to perform systems-level analyses. Currently, we aim at combining mouse models and genetic sensors to better understand the molecular adaptations of gene-environment interactions relevant for psychiatric and neurological diseases.

Homepage Department/Research Group


Selected Recent Publications

  • Brzózka MM, Rossner MJ (2013) Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4. Beh Brain Res 237, 348-356
  • Wehr MC, Holder M, Maile T, Saunders R, Jiang M, Instrell R, Howell M, Rossner MJ, Tapon N (2013) Salt-inducible kinases regulate growth through the Hippo signalling pathway. Nat Cell Biol 15, 61–71
  • Djannatjan MS, Galinski S, Fischer TM, Rossner M (2011) Studying G protein-coupled receptor activation using split-TEV assays. Analytical Biochmistry 412(2):141-52
  • Brzózka MM, Radyushkin R, Wichert SP, Ehrenreich H, Rossner M (2010) Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the forebrain. Biological Psychiatry 68(1): 33-40
  • Botvinnik A, Wichert SP, Fischer TM, Rossner M (2010) Integrated analysis of receptor activation and downstream signaling with EXTassays. Nature Methods 7(1):74-80
  • He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner M, Nishino S, Fu YH (2009) The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325(5942):866-70
  • Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner M, Kirchhoff F (2009) Split-cre complementation indicates coincident activity of different genes in vivo. PLoS ONE 4(1):e4286
  • Rossner M, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA (2008) Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS ONE 3(7):e2762
  • Begemann M, Sargin D, Rossner M, Bartels C, Theis F, Wichert SP, Stender N, Fischer B, Sperling S, Stawicki S, Wiedl A, Falkai P, Nave KA, Ehrenreich H (2008) Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches. Mol Med 14(9-10):546-52
  • Wehr MC, Reinecke L, Botvinnik A, Rossner M (2008) Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split TEV. BMC Biotechnol 8:55
  • Wehr MC, Laage R, Bolz U, Fischer TM, Grunewald S, Scheek S, Bach A, Nave KA, Rossner M (2006) Monitoring regulated protein-protein interactions using split TEV. Nature Methods 3(12):985-93