Milosevic, Ira, Dr.
Major Research Interests
The laboratory investigates fundamental aspects of synaptic vesicle recycling that have relevance to neurological and neurodegenerative diseases, using mouse and mammalian cells as a model system. A cutting edge genomic engineering is combined with the latest techniques of imaging and cell biology to study the processes that regulate synaptic vesicle formation. In a distinct but related strand of work, we are exploring the signaling processes that originate from altered neurotransmission and lead to neurodegeneration.
Homepage Department/Research Group
- Milosevic I*, Giovedi S*, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O’Toole E, Ferguson S, Cremona O, De Camilli P (2011) Recruitment of endophilin to clathrin coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72 (4), 587-601 *equal contribution
- de Wit H, Walter A, Milosevic I, Gulyás-Kovács A, Sørensen JB,Verhage M (2009) Four proteins that dock secretory vesicles to the target membrane. Cell 138 (5), 935-946
- Nagy G*, Milosevic I*, Mohrmann R, Wiederhold K, Walter AM, Sørensen JB (2008) The SNAP-25 linker as an adaptation toward fast exocytosis. Mol Biol Cell 19 (9), 3769-3781 *equal contribution
- Gulyás-Kovács A, de Wit H, Milosevic I, Kochubey O, Toonen R, Klingauf J, Verhage M, Sørensen JB. (2007) Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J Neurosci 27(32), 8676-8686. (accompanied by an editorial comment in J Neurosci 27 (32), i)