Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Milosevic, Ira, Dr.

  • since December 2012: Independent Group Leader at the European Neuroscience Institute Göttingen
  • 2007-2012: PostDoc, HHMI and Yale University School of Medicine, Dept. of Cell Biology, New Haven, CT, USA (advisor: Prof. Pietro De Camilli)
  • 2006: Ph.D., IMPRS Neurosciences, Georg August University Göttingen, Germany; thesis work performed at Max Planck Institute for Biophysical Chemistry, Dept. of Membrane Biophysics and Dept. of Biochemistry (advisors: Prof. Erwin Neher, Prof. Reinhard Jahn)
  • 2003: M.Sc., IMPRS Neurosciences, Georg August University Göttingen, Germany; thesis work performed at Max Planck Institute for Biophysical Chemistry, Dept. of Membrane Biophysics and Dept. of Biochemistry (advisors: Prof. Erwin Neher, Prof. Reinhard Jahn)
  • 2001: Diploma (Dipl. Ing.) in Molecular Biology University of Zagreb, Zagreb, Croatia; thesis work performed at Eötvös Lorand University, Dept. of Biochemistry, Budapest, Hungary and Ruder, Boskovic Institute, Dept. of Molecular Genetics, Zagreb, Croatia (advisors: Prof. Ivana Weygand-Durasevic, Prof. Laszlo Nyitray)

  • Major Research Interests

    The laboratory investigates fundamental aspects of exocytosis, endocytosis and synaptic vesicle recycling that have relevance to neurological and neurodegenerative diseases, using mouse and mammalian cells as a model systems. We combine genomic engineering, biochemistry, imaging (light and electron microscopy), cell biology and electrophysiology to study the processes that regulate synaptic vesicle formation. In a distinct but related strand of work, we are exploring the signaling processes that originate from altered neurotransmission and lead to neurodegeneration.

    Homepage Department/Research Group

    http://www.eni.gwdg.de/groups/synaptic-vesicle-dynamics

    Publications


    • Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C, Jorgensen EM (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98(6), 1184-1197
    • Farsi Z, Gowrisankaran S, Matija K, Rammner B, Woehler A, Mim C, Jahn R, Milosevic I (2018) Clathrin coat controls vesicle acidification by blocking vacuolar ATPase activity. eLife 7, doi: 10.7554/eLife.32569
    • Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, Milosevic I, Hanley J (2017) PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol 216(10), 3323-3338
    • Murdoch JD, Rostsoky C, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I (2016) Endophilin-A deficiency induces the FoxO3a-Fbxo32 network in the brain and causes dysregulation of autophagy and the ubiquitin-proteasome system. Cell Rep 17(4), 1071-1086
    • Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O’Toole E, Ferguson S, Cremona O, De Camilli P (2011) Recruitment of endophilin to clathrin coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72 (4), 587-601
    • de Wit H, Walter A, Milosevic I, Gulyás-Kovács A, Sørensen JB,Verhage M (2009) Four proteins that dock secretory vesicles to the target membrane. Cell 138 (5), 935-946
    • Nagy G*, Milosevic I*, Mohrmann R, Wiederhold K, Walter AM, Sørensen JB (2008) The SNAP-25 linker as an adaptation toward fast exocytosis. Mol Biol Cell 19 (9), 3769-3781 *equal contribution
    • Gulyás-Kovács A, de Wit H, Milosevic I, Kochubey O, Toonen R, Klingauf J, Verhage M, Sørensen JB. (2007) Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J Neurosci 27(32), 8676-8686. (accompanied by an editorial comment in J Neurosci 27 (32), i)