Milosevic, Ira, Dr.

  • since December 2012: Independent Group Leader at the European Neuroscience Institute Göttingen
  • 2007-2012: PostDoc, HHMI and Yale University School of Medicine, Dept. of Cell Biology, New Haven, CT, USA (advisor: Prof. Pietro De Camilli)
  • 2006: Ph.D., IMPRS Neurosciences, Georg August University Göttingen, Germany; thesis work performed at Max Planck Institute for Biophysical Chemistry, Dept. of Membrane Biophysics and Dept. of Biochemistry (advisors: Prof. Erwin Neher, Prof. Reinhard Jahn)
  • 2003: M.Sc., IMPRS Neurosciences, Georg August University Göttingen, Germany; thesis work performed at Max Planck Institute for Biophysical Chemistry, Dept. of Membrane Biophysics and Dept. of Biochemistry (advisors: Prof. Erwin Neher, Prof. Reinhard Jahn)
  • 2001: Diploma (Dipl. Ing.) in Molecular Biology University of Zagreb, Zagreb, Croatia; thesis work performed at Eötvös Lorand University, Dept. of Biochemistry, Budapest, Hungary and Ruder, Boskovic Institute, Dept. of Molecular Genetics, Zagreb, Croatia (advisors: Prof. Ivana Weygand-Durasevic, Prof. Laszlo Nyitray)

  • Major Research Interests

    The laboratory investigates fundamental aspects of exocytosis, endocytosis and synaptic vesicle recycling that have relevance to neuronal and brain functions, using mouse and mammalian cells as model systems. We combine biochemistry, imaging (light and electron microscopy), cell biology and electrophysiology to study the processes that regulate synaptic vesicle formation. In a distinct but related line of work, we are exploring the signaling processes that originate from altered neurotransmission and lead to neurodegeneration.

    Homepage Department/Research Group

    http://www.eni.gwdg.de/groups/synaptic-vesicle-dynamics

    Publications


    • Fonseca TB, Sánchez-Guerrero A, Milosevic I, Raimundo N (2019) Mitochondrial fission requires Drp1 but not dynamins. Nature 570(7761):E34-E42, doi: 10.1038/s41586-019-1296-y
    • Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C, Milosevic I, Moser T (2019) Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells. EMBO J 38(5), doi: 10.15252/embj.2018100116
    • Yambire KF, Fernández-Mosquera L, Steinfeld R, Muhle C, Ikonen E, Milosevic I, Raimundo N (2019) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. eLife 8, doi: 10.7554/eLife.39598
    • Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C, Jorgensen EM (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98(6), 1184-1197
    • Farsi Z, Gowrisankaran S, Matija K, Rammner B, Woehler A, Mim C, Jahn R, Milosevic I (2018) Clathrin coat controls vesicle acidification by blocking vacuolar ATPase activity. eLife 7, doi: 10.7554/eLife.32569
    • Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, Milosevic I, Hanley J (2017) PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol 216(10), 3323-3338
    • Murdoch JD, Rostosky C, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I (2016) Endophilin-A deficiency induces the FoxO3a-Fbxo32 network in the brain and causes dysregulation of autophagy and the ubiquitin-proteasome system. Cell Rep 17(4), 1071-1086
    • Giordano F, Saheki Y, Idevall-Hagren O, Colombo SF, Pirruccello M, Milosevic I, Gracheva EO, Bagriantsev SN, Borgese N, De Camilli P (2013) PI(4,5)P2-dependent and Ca2+-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell 153 (7), 1494-509
    • Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O’Toole E, Ferguson S, Cremona O, De Camilli P (2011) Recruitment of endophilin to clathrin coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72 (4), 587-601
    • de Wit H, Walter A, Milosevic I, Gulyás-Kovács A, Sørensen JB,Verhage M (2009) Four proteins that dock secretory vesicles to the target membrane. Cell 138 (5), 935-946