• 1993 Dr. sc. nat. (Chemistry) ETH Zürich, Switzerland


• 1993-1994 Postdoc (Laboratory of Prof. Dr. D. P. Curran, University of Pittsburgh, Pittsburgh, USA)


• 1994-1999 Habilitation (Laboratory of Prof. Dr. H. Kessler, Technical University Munich)


• 1998-1999 Visiting Professor for Organic Chemistry at LMU Munich


• 1999-2001 Professor for Organic Chemistry at the University of Würzburg


• 2000 Goering Visiting Professor for Organic Chemistry, University of Wisconsin, Madison, USA


• 2001 Full Professor at the Institute for Organic Chemistry at the University of Göttingen

Major Research Interests

Modification of biomolecules (peptides/proteins/nucleic acids) by organic synthesis allowing for new functions, specific recognition, or molecular architecture:
- Organization of peptide helices within lipid bilayers, formation of membrane channels
- Peptide/protein mediated membrane fusion
- Stabilization and functionalization of secondary structures (DNA and peptides)
- Design of DNA binding molecules, bending of DNA double strands
- Molecular switches
- Functionalization of knotted proteins
- Topology and dynamic sequence modification of biomolecules for catalysis
- Catalytic mechanism and inhibitors of orotidindecarboxylase



Homepage Department/Research Group

http://www.diederichsen.chemie.uni-goettingen.de/



Selected Recent Publications

• Stoller, S., Sicoli, G., Baranova, T. Y., Bennati, M., Diederichsen U. (2011) TOPP – A Novel Nitroxide-labeled Amino Acid for EPR Distance Measurements. Angew. Chem. Int. Ed. 50, 9743-9746.



• Lygina, A. S., Meyenberg, K., Jahn, R., Diederichsen, U. (2011) Transmembrane domain peptide/peptide nucleic acid hybride as SNARE protein model in vesicle fusion. Angew. Chem. Int. Ed. 50, 8597-8601.



• Nadler, A., Strohmeier, J., Diederichsen, U. (2011) Fluorescent deoxyguanosine mimic for investigating DNA hybridization and topology. Angew. Chem. Int. Ed. 50, 5392-5396.



• van den Bogaart, G., Thutupalli, S., Risselada, J. H., Meyenberg, K., Holt, M., Riedel, D., Diederichsen, U., Herminghaus, S., Grubmüller, H., Jahn, R. (2011) Synaptotagmin-1: a distance regulator acting upstream of SNARE nucleation? Nat. Struct. Mol. Biol. 18, 805-812.



• Schneggenburger, P. E., Müllar, S., Worbs, B., Steinem, C., Diederichsen, U. (2010) Molecular Recognition at the Membrane-Water Interface: Controlling Integral Peptide Helices by Off-Membrane Nucleobase Pairing. J. Am. Chem. Soc. 132, 8020-8028.