Marquardt, Till, Dr.
since 2007: independent research group leader, DFG Emmy Noether group leader at the European Neuroscience Institute, Göttingen
2001-2006: postdoctoral research associate and staff scientist with Samuel L. Pfaff at the Salk Institute for Biological Studies in La Jolla, California, USA
2001: Ph.D. with Peter Gruss at the Max-Planck Institute of Biophysical Chemistry, University of Göttingen
Adequate control of body motion and posture depends on elaborate circuitries that connect both motor and sensory neurons with the musculature. The central importance of these connections is illustrated by the debilitating consequences of diseases affecting motor neurons, such as Amyotrophic Lateral Sclerosis (ALS) and diabetic neuropathy. Our research aims at understanding the molecular mechanisms driving the assembly of functional neuromuscular circuitries during embryonic and postnatal development. This includes the study of cell surface-based signaling molecules that control motor and sensory axon connectivity in mice. Another research focus of the lab aims at identifying and characterizing novel mechanisms driving the functional specification of motor neurons within the context of operative neuromuscular circuitry. We extensively take advantage of mouse genetics in order to selectively trace and manipulate specific neuron populations. We combine this genetic approach with live 3D fluorescence (spinning disk) microscopy, as well as electrophysiological methods to elucidate the role of cell surface and nuclear receptor proteins in sensory-motor connectivity and functional neuron specification.
Homepage Department/Research Group
Selected Recent Publications
Marquardt T, Shirasaki R, Ghosh S, Carter N, Andrews SE, Hunter T, Pfaff SL (2005) Co-expressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane sub-domains. Cell 121, 127-139.
Gallarda B, Bonanomi D, Müller D, Brown A, Alaynick WA, Lemke G, Pfaff SL, Marquardt T (2008) Segregation of axial sensory and motor pathways through heterotypic trans-axonal signaling. Science 320, 233-236.
Wang L, Klein R, Zheng B, Marquardt T (2011) Anatomical coupling of sensory and motor nerve trajectory through axon tracking. Neuron 71, 263-277.
Bonanomi D, Chivatakarn O, Bai G, Lettieri K, Abdesselem H, Marquardt T, Pierchala BA, Pfaff SL (2012) Ret is a multifunctional co-receptor that integrates diffusible- and contact-axon guidance signals. Cell 148, 568-582.
Wang L, Marquardt T (2012) Live monitoring of heterotypic axonal interactions in vitro. Nature Protocols 7, 351-363.