Stühmer, Walter, Prof. Dr.
Professor of Neurophysiology, Director at the Max Planck Institute for Experimental Medicine1978 - 1980: PhD work with Dr. F. Conti in Camogli, Italy
1980 - 1983: Post Doc in the Department of Physiology and Biophysics in Seattle, USA, with Dr. W. Almers
1983 - 1992: Group leader at the Max Planck Institute for Biophysical Chemistry in Göttingen with Dr. E. Neher
1992 - present: Director of the Department Molecular Biology of Neuronal Signals at the Max Planck Institute for Experimental Medicine in Göttingen
Major Research Interests
The principal aim of the department "Molecular Biology of Neuronal Signals" is the study of signaling within cells and between cells. To this end, molecular biology, genetics and electrophysiology are used to elucidate structure-function relationships of membrane-bound proteins, expecially ion channels and receptors. Specific tools such as antibodies and toxins are developed and used to interfere with signaling pathways relevant for cell cycle control, ion selectivity and the secretion of cells in culture and in primary cells.
Homepage Department/Research Group:
Selected Recent Publications
Lazzarini, M., Martin, S., Mitkovski, M., Vozari, R.R., Stühmer, W. and Del Bel, E. (2013) Doxycycline restrains glia and confers neuroproteciotn in a 6-OHDA Parkinson model. Glia 61, 1084-1100. Doi: 10.1002/glia.22496
El Hady, A., Afshar, G., Broeking, K., Schlüter, O., Geisel, T., Stühmer, W. and Wolf, F. (2013) Optogenetic stimulation effectively enhances intrinsically generated network synchrony. Frontiers in Neural Circuits 7, 167. Doi: 10.3389/fncir.2013.00167
Issy, A.C., Fonseca, J.R., Pardo, L.A., Stühmer, W. and Del Bel, E. (2014) Hippocampal ether-à-go-go-1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition. Neurosci. Lett. 559, 13-17. Doi: 10.1016/j.neulet.2013.11.026
Urrego Blanco, D., Tomczak, A., Zahed, F., Stühmer, W. and Pardo, L.A. (2014) Potassium channels in cell cycle and cell proliferation. Phil. Trans¬. Royal Soc. B. 369. Doi: 10.1098/rstb.2013.0094
Pardo, L.A. and Stühmer, W. (2014) The roles of K+ channels in cancer. Nat. Rev. Cancer 14, 39-48. Doi: 10.1038/nrc3635