CRC Research Group ''Nanoscale Imaging of Cellular Dynamics''
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Open PhD Positions




Coherent X-Ray Imaging of Cells
(together mit Prof. Dr. T. Salditt)
The development of novel x-ray sources, such as free electron lasers (FEL) and highly coherent synchrotron sources opens up completely new possibilities for in situ imaging of biological cells. The aim of this project is to combine conventional channel-based microfluidics with FEL-comaptible, windowless flow of (cell-)suspension. This approach will help us to take advantage of the controlability of low Reynolds-number microfluidics (e.g. inducing changes in the cells by mixing in certain reagents) with the free jet streaming in vacuum which allows for FEL-applications.
Experience in programming, interest in interdisciplinary scientific questions, and a strong background in x-ray-, bio- or soft matter physics or a related field are required.

setup



FCS measurements in microfluidic devices
In collaboration with the group of Prof. Dr. Detlev Schild we are planning to combine fluorescence correlation spectroscopy (FCS) measurements and microfluidic techniques. This will allow to study the system of choice in close-to-physiological conditions and dynamically while taking advantage of the high resolution FCS offers.
The aim of this project is to develop and build a suitable setup including adaption of the software and designing microfluidic flow chambers for specified scientific questions. These could be, for example, the assembly kinetics of biological macromolecules.
Experience with microscopy and programming, interest in interdisciplinary scientific questions, and a strong background in bio- or soft matter physics, optics, or a related field are required.

MFdeviceFL



Projects for Bachelor's and Master's students

There are always open spots for Master‘s and Bachelor‘s students in our group. Topics include, for example:

  • light scattering (DLS) experiments in microfluidic devices

  • small angel x-ray (SAXS) studies in microfluidic devices

  • protein bundle dynamics in living cells

  • force measurement on single cells

  • microscopic imaging of “difficult” cells

  • analysis of intracellular networks





    • Contact

    For more information and to apply, please contact:
    Prof. Dr. Sarah Köster
    Georg-August-Universität Göttingen
    Institute for X-Ray Physics
    Friedrich-Hund-Platz 1, F.00.106
    37077 Göttingen, Germany
    phone: +49-551-39-9429
    email: sarah.koester@phys.uni-goettingen.de






    Universität Göttingen