Event
Circadian regulation, gene expression and the fly brain| Title of the event | Circadian regulation, gene expression and the fly brain |
| Series | Manfred Eigen Lecture |
| Organizer | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Speaker | Prof. Dr. Michael Rosbash |
| Speaker institution | Department of Biology, Brandeis University USA, Howard Hughes Medical Institute |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | The mechanism and genes that underlies circadian timing are conserved in all animals, from fruit flies to humans, and include a conserved set of transcription-translation feedback loops. This system also governs a large fraction of all gene expression in many if not most tissues, which explains why so much animal physiology (biochemistry, metabolism, endocrinology, behavior, sleep, etc.) is under temporal control. A large fraction of my current research focuses on the Drosophila brain, where ~150 central brain “clock” neurons cells play a prominent role in orchestrating the fly sleep-wake cycle. These cells share the central clock timekeeping mechanism but are otherwise remarkably heterogeneous from a molecular profiling point of view. Neuronal heterogeneity may be a general feature of the tiny fly brain (100,000 neurons) and help explain how it can orchestrate such an impressive array of complex behaviors. Time permitting, I will also discuss an additional topic, one that bridges the identification of RNA-binding protein targets to issues of neuroscience interest. |
| Date | Start: 26.11.2019, 14:00 Uhr Ende: 26.11.2019 , 15:00 Uhr |
| Location |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Manfred Eigen Hall Administration Building |
| Contact |
+49-551-2012010 helena.miletic@mpibpc.mpg.de |
| File attachment | Michael Rosbash_Manfred Eigen... |