Graduated in September 2011


Doctoral Thesis Project
Correlated and Further Dynamics in Proteins by NMR Spectroscopy


Doctoral Thesis Committee

• Griesinger, Christian, Prof. Dr. - NMR-based Structural Biology (MPI-bpc)


• Grubmüller, Helmut, Prof. Dr. - Theoretical and Computer-based Biophysics (MPI-bpc)


• Steinem, Claudia, Prof. Dr. - Organic and Biomolecular Chemistry (Uni-Che)

University Education

• 10/2007-09/2011 Max Planck Institute for Biophysical Chemistry / University of Göttingen / GGNB program Physics of Biological and Complex Systems


• 04/2005-09/2007 Georg August University Göttingen, Germany, Diplom, Chemistry, thesis: "Bestimmung der Dynamik von Ubiquitin in Lösung mittels orientierungsabhängiger NMR-Parameter"


• 04/2003-03/2005 Carl-von-Ossietzky-University, Oldenburg, Germany, Vordiplom, Chemistry

Publications

• Farès C, Lakomek NA, Walter KF, Frank BT, Meiler J, Becker S, Griesinger C. Accessing ns-micros side chain dynamics in ubiquitin with methyl RDCs. J Biomol NMR. 2009 Sep;45(1-2):23-44.


• Salmon L, Bouvignies G, Markwick P, Lakomek N, Showalter S, Li DW, Walter K, Griesinger C, Brüschweiler R, Blackledge M. Protein Conformational Flexibility from Structure-Free Analysis of NMR Dipolar Couplings: Quantitative and Absolute Determination of Backbone Motion in Ubiquitin. Angew Chem Int Ed Engl. 2009;48(23):4154-7.


• Lakomek NA, Lange OF, Walter KF, Farès C, Egger D, Lunkenheimer P, Meiler J, Grubmüller H, Becker S, de Groot BL, Griesinger C. Residual dipolar couplings as a tool to study molecular recognition of ubiquitin. Biochem Soc Trans. 2008 Dec;36(Pt 6):1433-7.


• Lakomek NA, Walter KF, Farès C, Lange OF, de Groot BL, Grubmüller H, Brüschweiler R, Munk A, Becker S, Meiler J, Griesinger C. Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR. 2008 Jul;41(3):139-55.


• Lange OF, Lakomek NA, Farès C, Schröder GF, Walter KF, Becker S, Meiler J, Grubmüller H, Griesinger C, de Groot BL. Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science. 2008 Jun 13;320(5882):1471-5.


• Lee D, Walter KF, Brückner AK, Hilty C, Becker S, Griesinger C. Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy. J Am Chem Soc. 2008;130: 13822-13823.


• Schmidt H, Himmel S, Walter KFA, Klaukien V, Funk M, Lee D. Transverse relaxation-optimized HCN experiment for tautomeric states of histidine sidechains. J Korean Mag Res Soc 2008;12: 89-95.