Wingender, Edgar, Prof. Dr.
Professor of BioinformaticsProfessor of Bioinformatics and Director of the Department of Bioinformatics, University of Göttingen, Medical School (since 2002)
CSO & President of BIOBASE GmbH, Wolfenbüttel (since 2001)
Staff scientist, project leader and head of the Research Group Bioinfomatics at the German Research Center for Biotechnology, Braunschweig (1986-2002)
Postdoc at the University of Marburg (1981-1986)
Dr. rer. nat., 1980, Technical University of Braunschweig
Major Research Interests
Our research is focused on the theroretical description of regulatory biological networks and their handling with computational tools.
Signal transduction processes and one of their major targets, the control of gene expression by transcriptional regulation, play a central role in nearly all cellular events such as cell cycle reglation, differentation, and response to any kind of environmental impact. We develop data models that represent eukaryotic promoter structures, the features of the transcriptional regulators (transcription factors), and the signaling pathways that influence their activities. We develop databases, populate them with the required information, formalize the representation of the objects in the databases and their relations by ontologies, and try to develop algorithms for the characterization of known regulatory components (e.g., genetic elements, regulatory molecules or pathways) and their identification in as yet uncharacterized systems. Modeling and simulation efforts will be extended onto the effects of pathological aberrations caused by mutations in regulatory components.
After rigorous verification, the tools developed during our research will be made available to the scientific community as Web-based resources.
Homepage Department/Research Group:
Selected Recent Publications
Shelest E, Kel AE, Gößling E, Wingender, E (2003) Prediction of potential C/EBP/NF-?B composite elements using the matrix-based search methods. In Silico Biol 2: 0007
Matys V, Fricke E, Geffers R, Gößling E, Haubrock M, Hehl R, Hornischer K, Karas D, Kel AE, Kel-Margoulis OV, Kloos DU, Land S, Lewicki-Potapov B, Michael H, Münch R, Reuter I, Rotert S, Saxel H, Scheer M, Thiele S, Wingender E (2003) TRANSFAC® : transcriptional regulation, from patterns to profiles. Nucleic Acids Res 31: 374-378
Liebich I, Bode J, Reuter I, Wingender E (2002). Evaluation of sequence motifs found in scaffold / matrix attached regions (S/MARs). Nucleic Acids Res 30: 3433-3442
Kloos DU, Choi C, Wingender E (2002) The TGF-?-Smad network: introducing bioinformatic tools. Trends Genet 18: 96-103
Schacherer F, Choi C, Götze U, Krull M, Pistor S, Wingender E (2001) The TRANSPATH signal transduction database: a knowledge base on signal transduction networks. Bioinformatics 17: 1053-1057
Kel AE, Kel-Margoulis OV, Farnham PJ, Wingender E, Zhang MQ (2001) Computer-assisted identification of cell cycle-related genes - new targets for E2F transcription factors. J Mol Biol 309: 99-120
Kel A, Kel-Margoulis O, Babenko V, Wingender E (1999) Recognition of NFATp/AP1 composite elements within genes induced upon the activation of immune cells. J Mol Biol 288: 353-376