Neumann, Heinz, Prof. Dr.
Professor of Biochemistry
- 2000: Degree in Chemistry, University of Tübingen
- 2001-2005: Doctoral Student, Universities of Tübingen, GER and Lausanne, CH
- 2005 PhD thesis “Structure and function of the VTC complex of S. cerevisiae", with Prof. Dr. Andreas Mayer, Universities of Tübingen and Lausanne, CH
- 2006-09: Postdoctoral fellowship with Dr. Jason Chin at the Medical Research Council, Laboratory of Molecular Biology (MRC-LMB) Cambridge, UK
- Since 2009: Junior Research Group Leader, University of Göttingen, Göttingen
Homepage Department/Research Group
Major Research Interest
Applied Synthetic Biology
Synthetic Biology is a new, actively growing field of the life sciences that combines elements from biology and engineering with the aim to design and create life forms with new, unprecedented properties and functions. Synthetic biologists have increased the coding potential of several organisms to allow genetic incorporation of additional “unnatural” amino acids into proteins. These unnatural amino acids have unique chemical or biophysical properties or carry naturally occurring (post-translational) modifications and are therefore fascinating new tools to investigate cellular processes.
Using these tools we develop new strategies to introduce spectroscopic probes into proteins to study the dynamic properties of chromatin. We are also interested in the effect of the post-translational acetylation of lysine residues on protein structure and function.
Selected Recent Publications
- Neumann H*, Wang K*, Davis L, Garcia-Alai M, Chin J W (2010) Encoding Multiple Unnatural Amino Acids via Evolution of a Quadruplet Decoding Ribosome. Nature 464: 441-444
- Neumann H, Slusarczyk A L, Chin J W (2010) De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. J Am Chem Soc 132, 2142-44
- Neumann H, Hancock S, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin J W (2009) A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol Cell 36,153-63
- Neumann H, Peak-Chew S Y, Chin J W (2008) Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. Nat Chem Biol 4, 232-4
- Neumann H, Hazen J L, Weinstein J, Mehl R A, Chin J W (2008) Genetically encoding protein oxidative damage. J Am Chem Soc 130, 4028-33
- Wang K*, Neumann H*, Peak-Chew S Y, Chin J W (2007) Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion. Nat Biotechnol 25, 770-7
* equally contributing authors