SK.Bio.7008: Molecular biology of HIV replication and pathogenesis (2 C, 1 SWS)
Learning outcome, core skills:
The students will learn the molecular mechanisms underlying the different steps of HIV replication, including entry, reverse transcription, genome integration, gene expression, assembly, release and maturation. Moreover, innate antiviral defenses and viral countermeasures will be discussed. In addition, insights into humoral immune responses against HIV and challenges associated with the generation of an effective vaccine will be provided. Finally, concepts and components of antiretroviral therapy will be introduced and the zoonotic origin of HIV will be discussed. Students attending the lectures will acquire an understanding of central mechanisms underlying HIV replication and pathogenesis and their blockade by immune responses and antiviral therapy.
Lecture: Molecular biology of HIV replication and pathogenesis (2 WHL)
Written examination (45 minutes)
The students should be able to respond to questions concerning basic aspects of HIV replication, pathogenesis, immune responses and antiviral therapy.
Recommended previous knowledge:
Number of repeat examinations permitted:
Maximum number of students:
Person responsible for module:
Prof. Dr. Stefan Pöhlmann