Diederichsen, Ulf, Prof. Dr.


  • 1993 Dr. sc. nat. (Chemistry) ETH Zürich, Switzerland
  • 1993-1994 Postdoc (Laboratory of Prof. Dr. D. P. Curran, University of Pittsburgh, Pittsburgh, USA)
  • 1994-1999 Habilitation (Laboratory of Prof. Dr. H. Kessler, Technical University Munich)
  • 1998-1999 Visiting Professor for Organic Chemistry at LMU Munich
  • 1999-2001 Professor for Organic Chemistry at the University of Würzburg
  • 2000 Goering Visiting Professor for Organic Chemistry, University of Wisconsin, Madison, USA
  • 2001 Full Professor at the Institute for Organic Chemistry at the University of Göttingen
  • 2005 – 2007 Dean of the Faculty of Chemistry
  • since 2015 Vice President for Research of the University of Göttingen





Major Research Interests

Modification of biomolecules (peptides/proteins/nucleic acids) by organic synthesis allowing for new functions, specific recognition, or molecular architecture:
- Organization of peptide helices within lipid bilayers, formation of membrane channels
- Peptide/protein mediated membrane fusion
- Stabilization and functionalization of secondary structures (DNA and peptides)
- Design of DNA binding molecules, bending of DNA double strands
- Molecular switches
- Functionalization of knotted proteins
- Topology and dynamic sequence modification of biomolecules for catalysis
- Catalytic mechanism and inhibitors of orotidindecarboxylase



Homepage Department/Research Group

http://www.uni-goettingen.de/de/571783.html


Selected Recent Publications


  • Hubrich BE, Kumar P, Neitz H, Grunwald M, Grothe T, Walla PJ, Jahn R, Diederichsen U (2018) PNA Hybrid Sequences as Recognition Units in SNARE-Protein-Mimicking Peptides. Angew. Chem. Int. Ed. 130, 15184-15192

  • Middel S, Panse CH, Nawratil S, Diederichsen U (2017) Native Chemical Ligation Directed by Photocleavable Peptide Nucleic Acid (PNA) Templates. ChemBioChem 18, 2328-2332

  • Rost U, Steinem C, Diederichsen U (2016) β-Glutamine-mediated Self-Association of Transmembrane β-Peptides within Lipid Bilayers. Chem. Sci. 7, 5900–5907

  • Sadek M, Berndt D, Milovanovic D, Jahn R, Diederichsen U (2016) Distance regulated vesicle fusion and docking mediated by beta-peptide nucleic acid SNARE protein analogs. ChemBioChem 17, 479-485

  • Vreja IC, Kabatas S, Saka SK, Kröhnert K, Höschen C, Opazo F, Diederichsen U, Rizzoli SO (2015) Secondary ion mass spectrometry of genetically-encoded targets. Angew. Chem. Int. Ed. 54, 5784–5788