Jarry, Hubertus, Prof. Dr.
Professor of Clinical and Experimental Endocrinology
- 1976 - 1980 University of Göttingen, study of biology, diploma degree in biochemistry, microbiology, organic chemistry
- 1980 - 1983 PhD thesis, Department of Biochemistry, University of Göttingen, PhD degree in
biochemistry, microbiology, organic chemistry (summa cum laude)
- until February 1985 German Primate Center Göttingen, Dept. Reproductive Biology
- March 1985 until March 1986 Michigan State University, Dept. Pharmacology and Toxicology
- since April 1986 Research Associate Dept. Clinical and Experimental Endocrinology University of Göttingen
- Januar 1991 Habilitation
- Dezember 1995 Promotion to Professor
Major Research Interests
The proper function of the GnRH pulse generator ist essential for reproduction of all mammals studied so far. GnRH pulses are a prerequisite for proper pituitary gonadotropin release. The neurochemical mechanisms leading to pulsatile GnRH release involve norepinephrine and gamma amino butyric acid (GABA) as most important neurotransmitters. In addition, other catecholamines, amino acid neurotransmitters and neuropeptides play a modulatory role in the function of the GnRH pulse generator. Many of the GABAergic neurons in the hypothalamus are estrogen-receptive. The mechanisms by which the estrogen receptors of the alpha and beta subtype regulate gene and protein expression of neurotransmitter-producing enzymes are at present a prime focus of interest. Induction of puberty is not a gonadal but a hypothalamic maturational process. The initiation of proper GnRH pulse generator function is the ultimate trigger signal for puberty which is currently investigated. Ageing involves also neuroendocrine mechanisms. The GnRH pulse generator function deteriorates in aged rats, mechanisms which involve a variety of catecholamines and amino acid neurotransmitters which are currently investigated. Steroidal feedback signals (of estradiol, progesterone, and glucocorticoids) are crucial for the development and proper function of the adult hypothalamus of which the molecular and neurochemical mechanisms are studied with cell biological and animal experimental tools. Proper function of the GnRH pulse generator is also of crucial importance for initiation of puberty and maintenance of normal menstrual cycles in women. Many of hitherto unexplained infertilities can be explained of malfunctioning GnRH pulse generators which are studied in a series of clinical experiments.
Selected Recent Publications
- Loutchanwoot P, Srivilai P, Jarry H. (2013) Effects of the natural endocrine disruptor equol on the pituitary function in adult male rats. Toxicology 304:69-75
- Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N, Vierk R, Jarry H, Rune GM. (2013) Endocrine regulation of estrogen synthesis in the hippocampus? Prog Histochem Cytochem. 2013; 48: 49-64
- Fester L, Prange-Kiel J, Zhou L, Blittersdorf BV, Böhm J, Jarry H, Schumacher M, Rune GM. (2012) Estrogen-regulated synaptogenesis in the hippocampus: sexual dimorphism in vivo but not in vitro. J Steroid Biochem Mol Biol. 131:24-9.
- Böttner M, Leonhardt S, Wuttke W, Wedel T, Jarry H. (2010) Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity. Biogerontology. 11:75-85.
- Böttner M, Leonhardt S, Wuttke W, Jarry H. (2007) Changes of expression of genes related to the activity of the gonadotrophin-releasing hormone pulse generator in young versus middle-aged male rats. J Neuroendocrinol. 19:779-87
- Zhou L, Lehan N, Wehrenberg U, Disteldorf E, von Lossow R, Mares U, Jarry H, Rune GM (2007) Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors. Exp Neurol 203: 72-81
- Breit A, Wolff K, Kalwa H, Jarry H, Buch T, Gudermann T (2006) The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. J Biol Chem 281: 37447-56
- Fester L, Ribeiro-Gouveia V, Prange-Kiel J, von Schassen C, Bottner M, Jarry H, Rune GM (2006) Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesis. J Neurochem 97: 1136-44