Mansouri, Ahmed, Prof. Dr.

Molecular Developmental Genetics

  • Diploma (Chemistry), Technical University, Braunschweig (Germany) 1975
  • Dr. rer. nat . Chemical Technology Institute, Technical University, Braunschweig (Germany), 1978
  • Postdoc at the Institute of Human Genetics in Göttingen (1982 - 1986)
  • Postdoc at the Miescher Institute in Tübingen (MPI) and at the Max Planck Institute of Immunbiology in Freiburg (Germany) (1986 - 1989)
  • Since 1989 Dept of Molecular Cell Biology at the MPI for Biophysical Chemistry in Göttingen
  • Habilitation (Molecular Developmental Genetics), University of Göttingen, Germany, 1999
  • Since 2005: Dr. Helmut Storz Stiftungsprofessur for “dopaminerge Stammzelltherapie”, Dept of Clinical Neurophysiology at the University of Göttingen

Major Research Interests

Studying the molecular mechanisms controlling cell fate destiny and diversity is of fundamental interest for understanding pathological processes and diseases. We are using mouse genetics to study the role of transcription factors during cell differentiation in the endocrine pancreas and in the ventral midbrain.

In the pancreas, we are interested in molecules that control the endocrine cell subtype specification. In addition, we are studying animal models to uncover molecular pathways promoting beta-cell regeneration in the adult pancreas.

In the midbrain the specification of dopaminergic neurons is under the control of several transcription and secreted factors. Specifically, we want to identify factors that interact with Lmx1 a/b in order to promote the generation of functionally distinct dopaminergic neuron populations.

Homepage Department/Research Group

Selected Recent Publications

  • Kordowich S, Collombat P, Mansouri A, Serup P. (2011). Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol 11: 52-67
  • Griesel G, Krug C, Yurlova L, Diaconu M, Mansouri A. (2011). Generation of knockout mice expressing a GFP-reporter under the control of the Lmx1a locus. Gene Expr Patterns 11(5-6): 345-358
  • Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Ole Madsen OD, Serup P, Heimberg H, Mansouri A (2009) The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into a - and subsequently b -cells. Cell 138:449-462
  • Dressel R, Schindehütte J, Kuhlmann T, Elsner L, Novota P, Baier PC, Schillert A, Bickeböller H, Herrmann T, Trenkwalder C, Paulus W, Mansouri A (2008) The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. PLoS ONE 3(7):e2622