Marquardt, Till, Prof. Dr.

  • Since 2012: European Research Council (ERC) grant holder
  • 2007-2012: Emmy Noether Young Investigator (DFG)
  • Since 2007: Research group leader and principal investigator at the European Neuroscience Institute, Göttingen
  • 2001-2006:Postdoctoral research associate (2001-2005), Damon Runyon Fellow (2002-2005) and staff scientist (2006) with Samuel L. Pfaff at the Salk Institute for Biological Studies, La Jolla, USA
  • 1997-2001: Diploma (Dipl. Biol.) and Ph.D. (Dr. rer. nat.) thesis research with Peter Gruss at the Max-Planck Institute of Biophysical Chemistry, Göttingen

  • Research interests
    My team employs a combination of molecular genetics, live-cell microscopy, electrophysiology and behavior analysis to study two key aspects of nervous system development and function: we exploit the unique position of motor neurons at the intersection of central nervous system and movement apparatus to resolve the molecular machineries promoting neuron functional specialization and to understand their contribution to neural network function (focus 1) and we study axon-axon- and axon-glia signaling mechanisms contributing to peripheral nervous system assembly or pathology (focus 2).

    Homepage Department/Research Group

    Selected Recent Publications

  • Gallarda, B., Bonanomi, D., Müller, D., Brown, A., Alaynick, W.A., Lemke, G., Pfaff, S.L, and Marquardt, T. (2008). Segregation of axial sensory and motor pathways through heterotypic trans-axonal signaling. Science 320: 233-236
  • Wang, L., Klein, R., Zheng, B., and Marquardt, T. (2011). Anatomical coupling of sensory and motor nerve trajectory through axon tracking. Neuron 71: 263-277
  • Wang, L. and Marquardt, T. (2012). Live monitoring of heterotypic axonal interactions in vitro. Nature Protocols 7: 351-363
  • Bonanomi, D., Chivatakarn, O., Bai, G., Lettieri, K., Abdesselem, H., Marquardt, T., Pierchala, B.A., and Pfaff, S.L. (2012). Ret is a multifunctional co-receptor that integrates diffusible- and contact-axon guidance signals. Cell 148: 568-582
  • Wang, L., Mongera, A., Bonanomi, D., Cyganek, L., Pfaff, S.L., Nüsslein-Volhard, N., and Marquardt, T. (2014). A conserved axon-type hierarchy governing peripheral nerve assembly. Development 141: 1875-1883
  • Müller, D., Cherukuri, P., Henningfeld, K., Poh, C.P., Wittler, L., Grote, P., Schlüter, O., Schmidt, J., Laborda, J., Bauer, S.R., Brownstone, R.M., and Marquardt, T. (2014). Dlk1 promotes a fast motor neuron biophysical signature required for peak-force execution. Science 343: 1264-1266

  • Further Reading

  • Wang, L., and Marquardt, T. (2013). What axons tell each other: axon-axon signaling in nerve and circuit assembly. Curr Opin Neurobiol. 23: 974-982