Marquardt, Till, Prof. Dr.

Since 2012: European Research Council (ERC) grant holder

2007-2012: Emmy Noether Young Investigator (DFG)

Since 2007: Research group leader and principal investigator at the European Neuroscience Institute, Göttingen

2001-2006:Postdoctoral research associate (2001-2005), Damon Runyon Fellow (2002-2005) and staff scientist (2006) with Samuel L. Pfaff at the Salk Institute for Biological Studies, La Jolla, USA

1997-2001: Diploma (Dipl. Biol.) and Ph.D. (Dr. rer. nat.) thesis research with Peter Gruss at the Max-Planck Institute of Biophysical Chemistry, Göttingen

Research interests
My team employs a combination of molecular genetics, live-cell microscopy, electrophysiology and behavior analysis to study two key aspects of nervous system development and function: we exploit the unique position of motor neurons at the intersection of central nervous system and movement apparatus to resolve the molecular machineries promoting neuron functional specialization and to understand their contribution to neural network function (focus 1) and we study axon-axon- and axon-glia signaling mechanisms contributing to peripheral nervous system assembly or pathology (focus 2).

Homepage Department/Research Group

http://www.eni.gwdg.de/index.php?id=169

Selected Recent Publications

Gallarda, B., Bonanomi, D., Müller, D., Brown, A., Alaynick, W.A., Lemke, G., Pfaff, S.L, and Marquardt, T. (2008). Segregation of axial sensory and motor pathways through heterotypic trans-axonal signaling. Science 320: 233-236

Wang, L., Klein, R., Zheng, B., and Marquardt, T. (2011). Anatomical coupling of sensory and motor nerve trajectory through axon tracking. Neuron 71: 263-277

Wang, L. and Marquardt, T. (2012). Live monitoring of heterotypic axonal interactions in vitro. Nature Protocols 7: 351-363

Bonanomi, D., Chivatakarn, O., Bai, G., Lettieri, K., Abdesselem, H., Marquardt, T., Pierchala, B.A., and Pfaff, S.L. (2012). Ret is a multifunctional co-receptor that integrates diffusible- and contact-axon guidance signals. Cell 148: 568-582

Wang, L., Mongera, A., Bonanomi, D., Cyganek, L., Pfaff, S.L., Nüsslein-Volhard, N., and Marquardt, T. (2014). A conserved axon-type hierarchy governing peripheral nerve assembly. Development 141: 1875-1883

Müller, D., Cherukuri, P., Henningfeld, K., Poh, C.P., Wittler, L., Grote, P., Schlüter, O., Schmidt, J., Laborda, J., Bauer, S.R., Brownstone, R.M., and Marquardt, T. (2014). Dlk1 promotes a fast motor neuron biophysical signature required for peak-force execution. Science 343: 1264-1266

Further Reading

Wang, L., and Marquardt, T. (2013). What axons tell each other: axon-axon signaling in nerve and circuit assembly. Curr Opin Neurobiol. 23: 974-982