Stoykova, Anastassia, Prof. Dr.

Adj. Professor of Developmental Biology

  • since 2010 Adj. Professor at the University of Göttingen
  • since 2008 Independent Research Group Leader MPI-bpc (W2, MPG Minerva Program)
  • 2002 - 2008 Research Group Leader, Dept. Mol Cell Biol, MPIPBC, Göttingen
  • 1998 Habilitation (developmental biology), Faculty of Medicine, University Göttingen
  • 1991 - 2002 Senior Research Scientist, Max Planck Institute for Biophysical Chemistry, Dept. Molecular Cell Biology, Göttingen
  • 1989 - 1991 Assistant Research Professor, Inst. Mol. Biol., Bulg. Acad. Sci., Sofia
  • 1989 Habilitation (neurochemistry), Sofia
  • 1987 Ph.D. Neurobiology, Institute Molecular Biology, Bulg. Acad. Sci., Sofia
  • 1973 - 1988 Research Associate, Bulgarian Academy of Sciences, Sofia
  • 1972 M.D., Institute of Medicine, Plovdiv, Bulg. Medical Academy

  • Major Research Interests

    Our research interest is focused on molecular mechanisms of patterning and neurogenesis in developing and adult brain with an emphasis on the mammalian corticogenesis. In mammalian cortex billions of neurons are ordered in six layers and multiple functional domains, acting as integrative and executive centers. The complex organization of the cortex arises during embryogenesis from a limited number of neural stem cells through processes, controlled by cell-type specific and temporally distinct transcriptional programs. We are interested to understand genetic mechanisms, controlled by transcription factors, for the specification of neuronal subtype identity, layer, and area formation in developing cortex. In another line of studies we are addressing epigenetic control mechanisms of cortical neurogenesis through the chromatin remodeling BAF-complex (mSWI/SNF) in developing and adult brain. The main niche for neurogenesis in the adult brain is the subventricular zone (SVZ) of the forebrain. In ongoing collaborative effort, we aim to elucidate at a genomic level the differential gene expression in SVZ upon ischemic injury of the primate (monkey) brain. The generated data base is useful in providing primite brain specific gene candidates, possibly involved in determining the limited reparative capacity of the damaged human brain.

    Homepage Department/Research Group:

    Selected Recent Publications

  • Doeppner TR, Herz J, Bähr M, Tonchev AB, Stoykova A (2018) Zbtb20 regulates developmental neurogenesis in the olfactory bulb and gliogenesis after adult brain injury. Molecular Neurobiology, May 11
  • Nguyen H, Kerimoglu C, Pirouz M, Pham, L, Kiszka KA, Sokpor G, Sakib MS, Rosenbusch J, Teichmann U, Seong RH, Stoykova A, Fischer A, Steiger J, Tuoc T (2018) Epigenetic regulation of BAF complexes limits neural stem cell proliferation by suppressing Wnt signaling in late embryonic development. Stem Cell Report, 10: 11734-1750
  • Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev AB, Sun G, Ronnenberg A, Shi Y, Steiger JF, Ehrenreich H, Stoykova A (2017) Ablation of BAF170 in developing and postnatal dentate girus affects neural stem cell proliferation, differentiation, and learning. Molecular Neurobiology, 564: 4618-4635
  • Tonchev AB, Tuoc TC, Rosenthal EH, Studer M, Stoykova A (2016) Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Molecular Brain, (9) 65
  • Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener RJ, Kiszka KA, Rosenbusch J, Seong RH, Kessel M, Fischer A, Stoykova A, Staiger JF, Tuoc T(2015) Loss of BAF (mSWI/SNF) complexes causes global transcriptional and chromatin state changes in forebrain development. Cell Reports,13:1842 -1854
  • Tylkowski MA, Yang K, Hoyer-Fender S, Stoykova A (2015) Pax6 controls centriole maturation in cortical progenitors through Odf2. Cellular and Molecular Life Sciences 72 (9): 1795-1809
  • Paul V, Tonchev AB, Henningfeld KA, Pavlakis E, Rust B, Pieler T, Stoykova A (2014) Scratch2 modulates neurogenesis and cell migration through antagonism of bHLH proteins in the developing neocortex. Cerebral Cortex 24 (3): 754-772
  • Tuoc TC, Boretius S, Sansom SN, Pitulescu M, Frahm J, Livesey FJ, Stoykova A (2013) Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Developmental Cell 25 (3): 256-269
  • Zembrzycki A, Chou SJ, Ashery-Padan R, Stoykova A, O'Leary DDM (2013) Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nature Neuroscience 16 (8): 1060--1067
  • Tuoc TC, Radyushkin K, Tonchev AB, Pinon MC, Ashery-Padan R, Molnar Z, Davidoff MS, Stoykova A (2009) Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. Journal of Neuroscience 29 (26): 8335-8349