Wodarz, Andreas, Prof. Dr.

Professor of Stem Cell Biology

  • Diploma Biology, University of Cologne, 1990
  • Dr. rer. nat. Developmental Biology, University of Cologne, 1993
  • Postdoc, Howard Hughes Medical Institute, Stanford University, 1994-1997
  • Junior Group Leader, Heinrich Heine University Düsseldorf, 1997-2004
  • Habilitation in Genetics, Heinrich Heine University Düsseldorf, 2001
  • Appointed as Head of the Department of Stem Cell Biology at the University of Göttingen, 2004
  • Appointed as Head of the Department of Anatomy and Cell Biology at the University of Göttingen, 2010

Homepage Department/Research Group:

Major Research Interests
The research activities in the Wodarz laboratory focus mainly on different aspects of the asymmetric division of neural stem cells. Asymmetric cell division is a fundamental mechanism for the generation of cell diversity in complex organisms. At the same time, asymmetric cell division is essential for the balance between stem cells and differentiating cells in an organism. Disturbances of this balance can cause severe diseases, including cancer and neurodevelopmental disorders. Asymmetric cell division is intricately linked to the control of apical-basal cell polarity, which is investigated in a second research focus. The establishment and maintenance of apical-basal cell polarity is connected to the regulation of planar cell polarity (PCP) and cell adhesion, especially in epithelial tissues. In this context, we investigate the function of the evolutionarily conserved Wnt signal transduction pathway in the regulation of PCP and cell adhesion.
The model organism of our research is mainly the fruit fly Drosophila melanogaster, as it is easily accessible to genetic manipulation and is very well suited for cell biological analyses using high-resolution light microscopy.

Selected Recent Publications

  • Gailite I, Egger-Adam D, Wodarz A (2012) The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila. Mol Biol Cell 23, 433-447
  • Morawe T, Honemann-Capito M, von Stein W, Wodarz A (2011) Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis. J Cell Biol 193: 71-80
  • Krahn MP, Bückers J, Kastrup L, Wodarz A (2010) Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. J Cell Biol 190: 751-760
  • Krahn MP, Klopfenstein D, Fischer N, Wodarz A (2010) Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. Curr Biol 20: 636-642
  • Koch CM, Honemann-Capito M, Egger-Adam D, Wodarz A (2009) Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genetics 5: e1000644
  • Kim S, Gailite I, Moussian B, Luschnig S, Goette M, Fricke K, Honemann-Capito M, Grubmüller H, Wodarz A (2009) Kinase activity independent functions of atypical protein kinase C in Drosophila. J Cell Sci 122: 3759-3771
  • Krahn MP, Egger-Adam D, Wodarz A (2009) PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. Dev Cell 16: 901-908
  • Zhang G, Breuer M, Förster A, Egger-Adam D, Wodarz A (2009) Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions. J Cell Sci 122: 535-545
  • Wodarz A, Näthke IS (2007) Cell polarity in development and cancer. Nat Cell Biol 9: 1016-1024
  • Wodarz A (2005) Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts. Curr Opin Cell Biol 17: 475-481
  • von Stein W, Ramrath A, Grimm A, Müller-Borg M, Wodarz A (2005) Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling. Development 132:1675-1686