Detox Journal Club

Each week, the DETOX journal club meets the latest papers in evolutionary genetics and plant / animal breeding. After a week of doing science for work, we can all benefit from the chance to detoxify our systems by talking in a fun, no-pressure setting. Papers cover all aspects of evolutionary genetics and breeding, giving us the chance to stay up-to-date on the literature in our own and related fields.

Regular attendance is not mandatory, just come when you can and/or when the paper interests you. Attendees do not need to be members or affiliates of any particular division or group, just scientists at any stage of their careers who are interested in the topics and papers we'll discuss.

The detox meeting is in-person. We are meeting at Gutenbergterrassen at 5 pm! Don't forget to read your papers.

We meet on Wednesday afternoons at 17:00 at Gutenbergterrassen (

The detox is in sleep at the moment until further announcement!

Detox schedule in reverse chronological order:

January 11, 2023: 

Taagen et al., 2022. If it ain't broke, don't fix it: evaluating the effect of increased recombination on response to selection for wheat breeding

December 7, 2022:

Zhang et al., 2021.On the use of GBLUP and its extension for GWAS with additive and epistatic effects

November 30, 2022:

Zhao et al., 2017. Patterns and Consequences of Subgenome Differentiation Provide Insights into the Nature of Paleopolyploidy in Plants.

November 23, 2022:

Bernerdo., 2009. Should maize doubled haploids be induced among F(1) or F (2) plants?

November 9, 2022:

Ramstein and Buckler., 2022. Prediction of evolutionary constraint by genomic annotations improves functional prioritization of genomic variants in maize.

November 2, 2022:

Beissinger et al., 2016. Recent demography drives changes in linked selection across the maize genome.

October 26, 2022:

Sun et al., 2022.Chromosome-scale and haplotype-resolved genome assembly of a tetraploid potato cultivar.

October 12, 2022:

Detox is canceled due to the CiBreed week.

October 5, 2022:

Yang et al., 2022. Target-oriented prioritization: targeted selection strategy by integrating organismal and molecular traits through predictive analytics in breeding.

September 21, 2022:

Müller et al., 2020. A single gene underlies the dynamic evolution of poplar sex determination.

August 31, 2022:

Barrick et al., 2009. Genome evolution and adaptation in a long-term experiment with Escherichia coli.

August 25, 2022:

Zou et al., 2020. Accumulation of genetic variants associated with immunity in the selective breeding of broilers.

August 17, 2022:

Raza et al., 2021. Omics: The way forward to enhance abiotic stress tolerance in Brassica napus L.

August 10, 2022:

Elhaik, 2021. Why most Principal Component Analyses (PCA) in population genetic studies are wrong.

July 27, 2022:

Mason et al., 2017. A user guide to the Brassica 60K Illumina Infinium™ SNP genotyping array.

July 20, 2022:

Barghi et al., 2017. Drosophila simulans: A Species with Improved Resolution in Evolve and Resequence Studies.

July 13, 2022:

Chao et al., 2022. Genetic loci associated with freezing tolerance in a European rapeseed (Brassica napus L.) diversity panel identified by genome-wide association mapping.

July 6, 2022:

Khunsriraksakul et al., 2022. Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies.

June 15, 2022:

Rex Bernardo., 2022. Outliers and their distribution in breeding populations.

June 8, 2022:

Birchler and Auger., 2000-2013. Biological Consequences of Dosage Dependent Gene Regulation in Multicellular Eukaryotes.

May 25, 2022:

Michel et al, 2022. Genetic mapping of flowering time and plant height in a maize Stiff Stalk MAGIC population.

May 18, 2022: 

No Detox meeting!

May 11, 2022:

L.R. Schaeffer, 2006. Strategy for applying genome-wide selection in dairy cattle

May 4, 2022:

Monroe et al, 2022.  Mutation bias reflects natural selection in Arabidopsis thaliana.

March 23, 2022:

Sun et al, 2022.  A role for heritable transcriptomic variation in maize adaptation to temperate environments.

March 16, 2022:

Montesinor-Lopez et al, 2021.   Using an incomplete block design to allocate lines to environments improves spares genome-based prediction in plant breeding. And, Gervasi and Schiestl, 2017. Real-time divergent evolution in plants driven by pollinators. 

March 9, 2022:

Montesinor-Lopez et al, 2021.  Using an incomplete block design to allocate lines to environments improves spares genome-based prediction in plant breeding.

March 2, 2022:

Gervasi and Schiestl, 2017.  Real-time divergent evolution in plants driven by pollinators. 

February 23, 2022:

Schouten et al, 2019.  Breeding has increased the diversity of cultivated tomatoes in the Netherlands. 

February 16, 2022:

Walkowiak et al, 2020.        Multiple wheat genomes reveal global variation in modern breeding.

February 9, 2022:

Due to the IPK Gatersleben lecture, detox was canceled.

February 2, 2022:

Bernardo, 2016.     Bandwagons I, too, have known.

January 26, 2022:

Jayakodi et al, 2020.       The barley pan-genome reveals the hidden legacy of mutation breeding.

January 19, 2022:

Cseh et al, 2021.       Exploring the legacy of Central European historical winter wheat landraces.

January 12, 2022:

He et al, 2015.       Prospects and limits of marker imputation in quantitative genetic studies in European elite wheat (Triticum aestivum L.).

December 15, 2021:

Zaidi and Mathieson, 2020.       Demographic history mediates the effect of stratification on polygenic scores.

December 8, 2021:

Jensen et al, 2020.       A sorghum practical haplotype graph facilitates genome-wide imputation and cost-effective genomic prediction.

December 1, 2021:

Campbell et al, 2005.       Demonstrating stratification in a European American population.

November 24, 2021:

Zhao et al, 2018.       Genome-wide association analysis and QTL mapping reveal the genetic control of cadmium accumulation in maize leaf.

November 17, 2021:

Morales et al, 2021.      Genomic signatures of selection for resistance to stripe rust in Austrian winter wheat.

November 10, 2021:

Berg et al, 2019.       Reduced signal for polygenic adaptation of height in UK Biobank.

November 3, 2021:

Burke et al, 2014.       Standing genetic variation drives repeatable experimental evolution in outcrossing populations of       Saccharomyces cerevisiae       .

October 27, 2021:

Detox resumes! Burke et al, 2014.       Standing genetic variation drives repeatable experimental evolution in outcrossing populations of       Saccharomyces cerevisiae      .

April 1 - September 30, 2021:

Detox recess for the summer semester.

March 17, 2021

Chen et al, 2021.      Genome-wide identification of agronomically important genes in outcrossing crops using OutcrossSeq.

March 10, 2021

Wang et al, 2019.       Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

March 03, 2021

Taagen et al, 2020     . Counting on Crossovers: Controlled Recombination for Plant Breeding

February 24, 2021

Galiano-Carneiro et al, 2020.      Intercontinental trials reveal stable QTL for Northern corn leaf blight resistance in Europe and in Brazil

February 17, 2021


February 10, 2021

Barghi et al, 2020.      Distinct Patterns of Selective Sweep and Polygenic Adaptation in Evolve and Resequence Studies.

February 3, 2021

Malosetti et al, 2013.       The statistical analysis of multi-environment data: modeling genotype-by-environment interaction and its genetic basis

January 27, 2021

Kim et al, 2021.      The patterns of deleterious mutations during the domestication of soybean.

January 20, 2021

John R Platt, 1964.      Strong Inference.

January 13, 2021

MB MORRISSEY et al, 2010.      The danger of applying the breeder's equation in observational studies of natural populations

January 6, 2021

Chris Schwartz et al, 2020     . CRISPR-Cas9-mediated 75.5-Mb inversion in maize

December 30, 2020

Year end holidays

December 23, 2020

Year end holidays

December 16, 2020

H. Allen Orr, 2005.     The genetic theory of adaptation: a brief history

December 9, 2020

Camus-Kulandaivelu et al, 2006.      Maize Adaptation to Temperate Climate: Relationship Between Population Structure and Polymorphism in the      Dwarf8      Gene.

December 2, 2020 (4:30 pm)

Timothy Beissinger     . Reverse genomic prediction: identifying important traits in breeding populations.

November 25, 2020

Camus-Kulandaivelu et al, 2006. Maize Adaptation to Temperate Climate: Relationship Between Population Structure and Polymorphism in the     Dwarf8     Gene    

November 18, 2020

Bellot et al, 2018.     Can Deep Learning Improve Genomic Prediction of Complex Human Traits?

November 11, 2020

Heslot et al, 2014.     Integrating environmental covariates and crop modeling into the genomic selection framework to predict genotype by environment interactions.

November 4, 2020

Boer et al, 2007.     A Mixed-Model Quantitative Trait Loci (QTL) Analysis for Multiple-Environment Trial Data Using Environmental Covariables for QTL-by-Environment Interactions, With an Example in Maize.

October 28, 2020

Doekes et al, 2019.     Inbreeding depression due to recent and ancient inbreeding in Dutch Holstein - Friesian dairy cattle.

October 21, 2020

Forsberg et al, 2017.     On the relationship between epistasis and genetic variance heterogeneity.

October 14, 2020

Heslot et al, 2014.     Integrating environmental covariates and crop modeling into the genomic selection framework to predict genotype by environment interactions. 

October 7, 2020

Romagnon et al, 2019.      Comparative performances of machine learning methods for classifying Crohn's Disease patients using genome-wide genotyping data.

September 30, 2020

Zhang et al, 2017     . Computer vision and machine learning for robust phenotyping in genome-wide studies.

September 23, 2020

Khromov et al. 2020.    Widespread selection against deleterious mutations in the Drosophila genome.

September 16, 2020

May et al, 2019.    Genome-wide associations and functional gene analyzes for endoparasite resistance in an endangered population of native German Black Pied cattle.

September 9, 2020

Soyk et al, 2020.    New Horizons for Dissecting Epistasis in Crop Quantitative Trait Variation.

September 2, 2020

Mollinari et al, 2020    . Unraveling the Hexaploid Sweetpotato Inheritence Using Ultra-Dense Multilocus Mapping.

August 26, 2020

Ramu et al, 2017.    Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation.

August 19, 2020

Kou et al, 2020    . Evolutionary genomics of structural variation in Asian rice (Oryza sativa) domestication.

August 12, 2020

Pinho Morais et al, 2020.       Using public databases for genomic prediction of tropical maize lines

August 5, 2020

Tamiru et al, 2020.     Genome wide association analysis of a stemborer egg induced “call-for-help” defense trait in maize 

July 29, 2020

Chen et al, 2020.      The genetic architecture of the maize progenitor, teosinte, and how it was altered during maize domestication

July 22, 2020

Tamiru et al, 2020.     Genome wide association analysis of a stemborer egg induced “call-for-help” defense trait in maize 

July 15, 2020

Liu et al, 2019.      Trans Effects on Gene Expression Can Drive Omnigenic Inheritance

July 8, 2020

Boyle et al., 2017.      An expanded view of complex traits: from polygenic to omnigenic

March 18 - July 2, 2020

In light of university restrictions on teaching-related events, Detox will be temporarily on hold to prevent the spread of Covid-19. 

March 11, 2020

Yang et al, 2017     . Concepts, estimation and interpretation of SNP-based heritability

March 4, 2020

Detox canceled for PhD student retreat in Schierke.

February 26, 2020

Xavier et al, 2018.     Genome-Wide Analysis of Grain Yield Stability and Environmental Interactions in a Multiparental Soybean Population

February 19, 2020

Swarts et al, 2017.     Genomic estimation of complex traits reveals ancient maize adaptation to temperate North America

February 12, 2020

Detox canceled do to GPZ meeting.

February 5, 2020

Zeng et al    , 2018. Signatures of negative selection in the genetic architecture of human complex traits

(bonus paper:     Guo et al, 2019    )

January 29, 2020

A throw-back detox suggested by Baris. Wear your best 90's flannel, blazer, or white-washed jeans:   Khairallah et al   , 1998. Comparison of QTLs mapped in RILs and their test-cross progenies of tropicalmaize for insect resistance and agronomic traits

January 22, 2020

Fulop et al, 2016   . A New Advanced Backcross Tomato Population Enables High Resolution Leaf QTL Mapping and Gene Identification

January 15, 2020

Detox canceled for the DNPW colloquium. Prof. Scholten will be present at 4:15 p.m. in room L01.

January 8, 2020

Liu et al, 2019.    Genome-wide identification and analysis of heterotic loci in three maize hybrids

January 1, 2020

No Detox - Public holiday

December 25, 2019

No Detox - Public holiday

December 18, 2019
Monnahan et al. 2015.    Epistasis Is a Major Determinant of Additive Genetic Variance in Mimulus guttatus  

December 11, 2019
Roessler et al, 2019.     The genome-wide dynamics of purging during selfing in maize

December 4, 2019

Zhang et. al. 2019      . The genetic basis of inbreeding depression in potato

November 27th, 2019

Detox canceled to allow attendance of DNPW colloquium. Prof. Neugart will be present at 4:15 p.m. in room L01.

November 20, 2019

Novembre et al, 2008     . Gene's Mirror Geography within Europe. 

November 13th, 2019

Detox canceled to attend DNPW colloquium. Tim wants to be present at 4:15 p.m. in room L01.

November 6th, 2019

Cordell, 2002.     Epistasis: what it means, what it does not mean, and statistical methods to detect it in humans

October 30th, 2019

Detox canceled to attend DNPW colloquium. Prof. Rostas wants to present at 4:15 pm in room L01.

October 23, 2019

Kerin et al. 2019.    Gene-environment interactions using a Bayesian whole genome regression model 

October 16, 2019

Turner-Hissong, et al. Evolutionary insights into plant breeding. 

October 9th, 2019

Detox canceled due to Eucarpia conference in Munich.

October 2, 2019

Lowry et al. 2019    QTL × environment interactions underlie adaptive divergence in switchgrass across a large latitudinal gradient  

September 25, 2019
Gage et al. 2018    Selection Signatures Underlying Dramatic Male Inflorescence Transformation During Modern Hybrid Maize Breeding 

September 18, 2019

Yang et al. 2019    Genome assembly of a maize incorporated line provides insights into structural variation and crop improvement 

September 11th, 2019

Uricchio 2019    Evolutionary perspectives on polygenic selection, missing heritability, and GWAS 

September 4, 2019

Voss-Fels et al. 2019    Breeding improves wheat productivity under contrasting agrochemical input levels 

 -------------------------------------------------- -------------------------------------------------- -------------

Detox Hiatus: 2018- July 2019

Detox wants to take a break while relocates from Missouri, USA to Göttingen, Germany. If you are at MU, check out the DataPhiles group instead! Info here:    DataPhiles! 


February 2018

February 22 Detox Extravaganza / Tim Send off

To celebrate Tim's last Detox in Columbia, we'll spend an hour discussing each of the following three papers at three different locations. We'll start at Craft Beer Cellar an hour ago than usual, at 4:00, to discuss citrus domestication (paper # 1). At 5:00 we'll grab food at Seol Taco before heading to Gunter Hans to talk about earth-GWAS (paper # 2). At 6:00 we'll go to The Understudy where we'll discuss the power of PCA (paper # 3).

Wu et al. 2018     Genomics of the origin and evolution of Citrus 
Lin et al. 2017     Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by eRD-GWAS 
Novembre et al. 2008     Genes mirror geography within Europe

February 15

Pitchers et al. 2017    The power of a multivariate approach to genome-wide association studies: shape An example with Drosophila melanogaster wing    Dr. Dworkin wants to give a DBS seminar on Feb 20!

February 8th

Instead of detox, consider attending the    MU Plant Research Symposium

February 1

Mathew et al.  Detection of Epistasis for Flowering Time Using Bayesian Multilocus Estimation in a Barley MAGIC Population

Jan 2018

January 25th

Tilk et al.    High accuracy haplotype-derived allele frequencies from ultra-low coverage pool-seq samples

Jan 18

Zhao and Begun    Genomics of parallel adaptation at two timescales in Drosophila

January 11th

Zhao and Begun    Genomics of parallel adaptation at two timescales in Drosophila    Canceled due to hazardous weather

January 4th

Cornejo et al    . Genomic insights into the domestication of the chocolate tree, Theobroma cacao L.

December 2017

December 28th

Like the rest of the University, Detox wants to be closed this week. Happy New Year!

December 21st

Senn 2011    Francis Galton and regression to the mean

December 14th

Schrider and Kern, 2017    Machine Learning for Population Genetics: A New Paradigm

December 7th

Falconer 1992    Early Selection Experiments

November 2017

November 30th

Gage et al. 2017    The effect of artificial selection on phenotypic plasticity in maize

Nov 16 #TBT

Falconer 1992    Early Selection Experiments

November 9th

Santos et al.  Taxon-restricted genes at the origin of a novel access to a new environment

November 2

Bosse et al.  Recent natural selection causes adaptive evolution of an avian polygenic trait

October 2017

October 26th

Chari et al.  Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

October 19

Yang et al.  Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize   We're going to Lucky's Market again this week. Soon we'll vote on the regular destination. Location:

October 12

Noa Liscovitch-Brauer et al. Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods   We're going to give Lucky's Market a try this week. Instead of Craft Beer Cellar, we'll meet at Lucky's. Location: 

october 5

Goiffon et al.  Improving Response in Genomic Selection with a Population-Based Selection Strategy: Optimal Population Value Selection

September 2017

Sep 28

Edwards et al.  Genomic Prediction for Quantitative Traits Is Improved by Mapping Variants to Gene Ontology Categories in Drosophila melanogaster

Sep 21

Bromham et al.  Exploring the Relationships between Mutation Rates, Life History, Genome Size, Environment, and Species Richness in Flowering Plants

Sep 14

Alguillon et al.  Deconstructing isolation-by-distance: The genomic consequences of limited dispersal

Sep 7

No Detox - Go to the    Tomato festival!

August 2017

Aug 31

Guerrero et al.  Pervasive antagonistic interactions among hybrid incompatibility loci

Aug 24

Swarts et al.  Genomic estimation of complex traits reveals ancient maize adaptation to temperate North America

Aug 17

Noble et al.  Polygenicity and epistasis underlie fitness-proximal traits in the Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel

Aug 10

Cheng et al.  Subgenome parallel selection is associated with morphotype diversification and convergent crop domestication in Brassica rapa and Brassica oleracea

August 3

Venkat et al   Multinucleotide mutations cause false inferences of positive selection

July 2017

July 27

Grauer   An upper limit on the functional fraction of the human genomeXs

July 20

Monnahan and Kelly   The Genomic Architecture of Flowering Time Varies Across Space and Time in Mimulus guttatus

July 13

Fleming et al.  Genomic Comparison of Indigenous African and Northern European Chickens Reveals Putative Mechanisms of Stress Tolerance Related to Environmental Selection Pressure

July 6

Boyle et al.  An Expanded View of Complex Traits: From Polygenic to Omnigenic

June 2017

June 29

Zhou et al. The Evolutionary Genomics of Grape (Vitis vinifera ssp. Vinifera) Domestication 

June 22

Liu et al.  Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies

June 15

Han et al.  Clustering of 770,000 genomes reveals post-colonial population structure of North America

June 8

Malinski et al.  Whole Genome Sequences Of Malawi Cichlids Reveal Multiple Radiations Interconnected By Gene Flow

June 1

Sauvage et al.  Domestication rewired gene expression and nucleotide diversity patterns in tomato

May 2017

May 25

Chan et al.  The Complex Genetic Architecture of the Metabolome

May 18

Barber and Elde   Escape from bacterial iron piracy through rapid evolution of transferrin

May 11

Shen et al.  Contentious relationships in phylogenomic studies can be driven by a handful of genes

may 4

Huang et al.  Experimental Evolution of Gene Expression and Plasticity in Alternative Selective Regimes

April 2017

Apr 27

Zhang et al.  Genetic Basis of Melanin Pigmentation in Butterfly Wings

Apr 20

Thalmann et al.  The evolution of sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A   In honor of my new backyard chicks, which include one of the type described here

Apr 13

Forsberg and Carlborg   On The Relationship Between Epistasis And Genetic Variance-Heterogeneity

April 6th

Porto et al.  Evolution of the Genotype-to-Phenotype Map and the Cost of Pleiotropy in Mammals

March 2017

March 30

Graves et al.  Genomics of Parallel Experimental Evolution in Drosophila

March 23

Burke et al.  Standing Genetic Variation Drives Repeatable Experimental Evolution in Outcrossing Populations of Saccharomyces cerevisiae

March 16

Forsberg et al.  Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast

March 9

Josephs et al.  What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?

March 2

Imprialou et al.  Genomic Rearrangements Considered as Quantitative Traits

February 2017

February 23   This discussion will be in anticipation of Ruth Shaw's BioSci seminar the following Tuesday, February 28

Shaw and Shaw   Quantitative genetic study of the adaptive process

February 16

Nam et al.  Evidence that the rate of strong selective sweeps increases with population size in the great apes

February 9

Lillie et al.  Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens

February 2

Instead of Detox, go to the  MU Pioneer Plant Science Symposium !

Jan 2017

Jan 26

Siddiq et al, 2016  Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster

Jan 19

Brzyski et al, 2017  Controlling the Rate of GWAS False Discoveries

Jan 12

No detox

Jan 5

No detox

December 2016

December 29

No Detox -- You should be writing!

Dec 22

No Detox -- Read on your own

December 15

No Detox -- Good luck on finals!

December 8

Sicard et al, 2016  Standing genetic variation in a tissue-specific enhancer underlies selfing-syndrome evolution in Capsella

December 1

Yang et al, 2016  Incomplete dominance of deleterious alleles contribute substantially to trait variation and heterosis in maize

November 2016

Thursday, November 24, 2016

thanksgiving Discuss a good paper with non-scientist family and friends!

Thursday, November 17, 2016

Gould et al  Pooled ecotype sequencing reveals candidate genetic mechanisms for adaptive differentiation and reproductive isolation

Thursday, November 10, 2016

Natarajan et al  Predictable convergence in hemoglobin function has unpredictable molecular underpinnings

Thursday, November 3, 2016

Petkova et al  Visualizing spatial population structure with estimated effective migration surfaces

October 2016

Thursday, October 27, 2016

Yang et al Common SNPs explain a large proportion of the heritability for human height

Thursday, October 20, 2016

Bosse et al  Artificial selection on introduced Asian haplotypes shaped the genetic architecture in European commercial pigs

Thursday, October 13, 2016

Johnsson et al  Feralization targets different genomic loci to domestication in the chicken

Thursday, October 6, 2016

Zhao et al.  Breeding signature of combining ability improvement revealed by a genomic variation map from recurrent selection population in Brassica napus

September 2016

Thursday, September 29, 2016

Rougemont et al.  Inferring the demographic history underlying parallel genomic divergence among pairs of parasitic and nonparasitic lamprey ecotypes

Thursday, September 22, 2016

Abdollahi-Arpanahi et al.  Differential contribution of genomic regions to marked genetic variation and prediction of quantitative traits in broiler chickens

Thursday, September 15, 2016,  We'll have an important visitor, Sarah Turner from the University of Wisconsin, participating in this Detox

Josephs and Wright  On the Trail of Linked Selection

Thursday, September 8, 2016,  this will be good reading before John Kelly's IPG seminar on September 12

Kelly et al.  The Genomic Signal of Partial Sweeps in Mimulus guttatus

Thursday, September 1, 2016

Martin and Orgogozo  The Loci of Repeated Evolution: A Catalog of Genetic Hotspots of Phenotypic Variation

August 2016

Thursday, August 25, 2016

Schrider et al.  Effects of linked selective sweeps on demographic inference and model selection

Thursday, August 18, 2016

Lamichhaney et al.  A beak size locus in Darwin's finches facilitated character displacement during a drought

Thursday, August 11, 2016

Schrider et al.  Effects of linked selective sweeps on demographic inference and model selection

Thursday, August 4, 2016

Lan et al.  Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals

July 2016

Thursday, July 28, 2016

Fuchsberger et al.  The genetic architecture of type 2 diabetes

Thursday, July 21, 2016

Boyko et al.  A Simple Genetic Architecture Underlies Morphological Variation in Dogs

Thursday, July 14, 2016

Battagin et al.  Effect of manipulating recombination rates on response to selection in livestock breeding programs

NOTE FOR JULY 14: We will try meeting at Gunter Hans (7 Hitt Street) for a change of pace

Thursday, July 7, 2016

Merotto et al.  Evolutionary and social consequences of introgression of NON-transgenic herbicide resistance from rice to weedy rice in Brazil

June 2016

Thursday June 30, 2016

Mitteroecker et al.  Multivariate Analysis of Genotype - Phenotype Association

Tuesday June 23, 2016

Tian et al.  The Dissection of Expression Quantitative Trait Locus Hotspots

Tuesday June 16, 2016

Sadhu et al.  CRISPR-directed mitotic recombination enables genetic mapping without crosses

Thursday June 9, 2016

Dittmar et al.  Factors influencing the effect size distribution of adaptive substitutions

Thursday June 2, 2016

Gallaher et al.  Chlamydomonas Genome Resource for Laboratory Strains Reveals a Mosaic of Sequence Variation, Identifies True Strain Histories, and Enables Strain-Specific Studies

May 2016

Thursday, May 26, 2016

Detox canceled due to conflict with   IPG Symposium  .

Thursday, May 19, 2016

Field et al.  Detection of human adaptation during the past 2,000 years

Thursday, May 12, 2016

Barrett and Hoekstra   Molecular spandrels: tests of adaptation at the genetic level

Thursday, May 5, 2016

McManus et al.  Population Genetic Analysis of the DARC Locus (Duffy) Reveals Adaptation from Standing Variation Associated with Malaria Resistance in Humans

April 2016

Thursday April 28, 2016

Wang et al.  Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

Thursday April 21, 2016

Allaby et al.  Surprisingly low limits of selection in plant domestication

Thursday April 14, 2016

Boitard et al.  Inferring Population Size History from Large Samples of Genome-Wide Molecular Data - An Approximate Bayesian Computation Approach

Thursday April 7, 2016

Sheehan and Song     Deep learning for population genetic inference

March 2016

Thursday March 31, 2016

Pavlidis et al.  A Critical Assessment of Storytelling: Gene Ontology Categories and the Importance of Validating Genomic Scans

Thursday, March 24, 2016

Zhang et al.  Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-dose Ultraviolet Radiation in High-altitude Environments

Thursday March 17, 2016

Lamichhaney et al.  Population-scale sequencing reveals genetic differentiation due to local adaptation in Atlantic herring

Thursday, March 10, 2016 (     Requested by Libby     )

Huang et al.  Epistasis dominates the genetic architecture of Drosophila quantitative traits

Thursday March 3, 2016

MacLeod et al.  Exploiting biological priorities and sequence variants enhances QTL discovery and genomic prediction of complex traits

February 2016

Thursday, February 25, 2016

Swinnen et al.  Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop Improvement

Thursday, February 18, 2016

Davies et al.  Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

Thursday, February 11, 2016

Cubillos, et al.  High-Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population

Thursday, February 4, 2016

Rausher and Delph     Commentary: When does understanding phenotypic evolution require identification of the underlying genes?

Jan 2016

Thursday, January 28

Decker et al.  A novel analytical method, Birth Date Selection Mapping, detects response of the Angus (Bos taurus) genome to selection on complex traits

Thursday, January 21, 2016

Marsden et al.  Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

Thursday, January 14, 2016

Henn, et al.  Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

Thursday, January 7, 2016

No Detox - Winter Holiday

December 2015

Thursday December 31, 2015

No Detox - Winter Holiday

Thursday, December 24, 2015

No Detox - Winter Holiday

Thursday, December 17, 2015

Sellis, et al.  Empirical evidence for heterozygous advantage in adapting diploid populations of Saccharomyces cerevisiae

Thursday, December 10, 2015

Exome Aggregation Consortium et al.  Analysis of protein-coding genetic variation in 60,706 humans

Thursday, December 3, 2015

Lamichhaney et al.  Structural genomic changes underlying alternative reproductive strategies in the ruff (      Philomachus pugnax      )

November 2015

Thursday, November 26, 2015

No DETOX - Thanksgiving

Thursday, November 19, 2015 ( 5pm start )

Monnahan et al.  Epistasis Is a Major Determinant of the Additive Genetic Variance in       Mimulus guttatus

Thursday November 12, 2015

Mikheyev et al., 2015  Museum samples reveal rapid evolution by wild honey bees exposed to a novel parasite