Research Topics: Chemical Biology and Peptide Design
Design, synthesis and characterisation of small protein folding motifs with focus on the coiled-coil motif and the WW domain. Application of the de novo designed peptide components in the design of small functional peptide devices.
- De novo design and redesign of small protein folding motifs
- Structural analysis with biophysical methods such as CD spectroscopy, NMR spectroscopy and analytical ultracentrifugation
- Organic synthesis of linkers and non-proteinogenic amino acids
- Application of designed peptide building blocks as templates for chemical reactions, as catalysts and as association tools in the synthesis of molecular libraries