Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences

Lingor, Paul, Prof. Dr.*

Professor of Neurology


  • since 09/2012: associate professor for neurology (tenured) and deputy director at the Dept. of Neurology, University Medicine Göttingen
  • since 2011: head of the outpatient clinic for movement disorders
  • 2011: board certification in neurological intensive care
  • since 2010: consultant neurologist
  • 2009: board certification in neurology
  • 2001-2010: resident and research associate Dept. of Neurology, University Medicine Göttingen
  • 2001: MD Ruprecht-Karls-Universität Heidelberg



Major Research Interests

  • Pathophysiology of neurodegeneration, especially Parkinson's disease and motoneuron diseases
  • Mechanisms of axonal degeneration, role of iron in neurodegeneration
  • Biomarkers for neurodegenerative diseases from blood, CSF and tear fluid
  • Disease-modifying therapeutic strategies for degenerative CNS disorders, translational clinical trials


    • Homepage Department/Research Group

    http://www.baehrlab.med.uni-goettingen.de/staff_lingor.html


    Selected Recent Publications


    • Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P. Fasudil attenuates aggregation of ?-synuclein in models of Parkinson?s disease. Acta Neuropath Commun. 2016 Apr 22;4:39. doi: 10.1186/s40478-016-0310-y.
    • Zhang JN, Michel U, Lenz C, Friedel CC, Köster S, d?Hedouville Z, Tönges L, Urlaub H, Bähr M, Lingor P*, Koch JC*. Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration. Sci Rep 2016 Nov 15;6:37050. doi: 10.1038/srep37050. *shared last authorship.
    • Tönges L, Günther R, Suhr M, Jansen J, Balck A, Saal KA, Barski E, Nientied T, Götz A, Koch JC, Müller BK, Weishaupt J, Sereda MW, Hanisch UK, Bähr M, Lingor P. Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis. Glia. 2014 Feb;62(2):217-32. doi: 10.1002/glia.22601. Epub 2013 Dec 6.
    • Tönges L, Frank T, Tatenhorst L, Saal KA, Koch JC, Bähr M, Weishaupt J, Lingor P. Inhibition of Rho Kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson?s disease. Brain. 2012 Oct 19. Nov;135(Pt 11):3355-70. doi: 10.1093/brain/aws254.
    • Koch JC, Knöferle J, Tönges L, Michel U, Bähr M, Lingor P: Imaging of rat optic nerve axons in vivo. Nature Protocols. 2011 Nov 3;6(12):1887-96. doi: 10.1038/nprot.2011.403.
    • Knöferle J, Koch JC, Ostendorf T, Tönges L, Michel U, Planchamp V, Vutova P, Stadelmann C, Brück W, Bähr M, Lingor P: Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6064-9. Epub 2010 Mar 15.
    • Planchamp V, Bermel C, Tönges L, Ostendorf T, Kügler S, Reed JC, Kermer P, Bähr M, Lingor P: BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity. Brain. 2008 Oct;131(Pt 10):2606-19.
    • Lingor P*, Tönges L*, Pieper N, Bermel Ch, Barski L, Planchamp V, Bähr M: ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain. 2008 Jan;131(Pt 1):250-63. * shared first authorship.
    • Lingor P, Koeberle PD, Kügler S, Bähr M: Downregulation of apoptosis mediators by RNA interference inhibits axotomy-induced retinal ganglion cell death in vivo. Brain 2005 Mar;128(Pt 3):550-8.