Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Neef, Andreas, Dr.

  • 1994-2000 undergraduate and graduate in Physics, University of Jena, Germany
  • 1997-2000 research and graduate student at the Max-Planck research group "Molecular and Cellular Biophysics", Jena
  • 2000 Diploma in Physics, University of Jena, Germany
  • 2000 Visiting scientist at the MRC Laboratory of Molecular Biology Cambridge, Great Britain
  • 2001-2004 PhD student at the institute for biological information processing in the research centre Jülich
  • 2004 PhD in Biochemistry (Dr.rer.nat), University Cologne
  • 2004-2005 Postdoctoral fellow at the research centre Juelich
  • 2005-2006 Postdoctoral fellow at the Bernstein Center for Computational Neuroscience (BCCN), Göttingen
  • 2006-2013 Bernstein fellow at the BCCN and BFNT Göttingen
  • since May 2013 Group leader "Biophysics of neural computation" at the BCCN Göttingen

Major Research Interests

    My research covers various fields of neuroscience and ion channel biophysics. In my BCCN group Biophysics of neural encoding we focus on those key properties of neuronal systems that determine performance of information encoding. This can be the resupply of vesicles at a synapse (Holt et al. 2004, Neef et al. 2007) or the speed of action potential initiation. My goal is then to obtain a quantitative understanding of the system performance, which includes precision measurements of biopyhsical properties, structure, and function of neuronal elements. Sometimes it also requires the development of new experimental or numerical methods (e.g. Neef et al. 2007, Agudelo-Toro and Neef 2014, Yang et al. 2015). In collaboration with colleagues and friends I address problems from single molecule diffusion to non-invasive brain stimulation (e.g. Weiß et al. 2013, Rotem et al. 2014).

Homepage Department/Research Group

Selected Recent Publications

  • Yang Y, Ramamurthy B, Neef A, Xu-Friedman MA (2016) Low Somatic Sodium Conductance Enhances Action Potential Precision in Time-Coding Auditory Neurons. J Neurosci. 36: 11999-12009. doi:10.1523/JNEUROSCI.1475-16.2016

  • Stern S, Agudelo-Toro A, Rotem A, Moses E, Neef A (2015) Chronaxie Measurements in Patterned Neuronal Cultures from Rat Hippocampus. PLoS ONE. 10: e0132577. doi:10.1371/journal.pone.0132577

  • Neef NE, Hoang TNL, Neef A, Paulus W, Sommer (2015) Speech dynamics are coded in the left motor cortex in fluent speakers but not in adults who stutter. Brain. 138: 712?725. doi:10.1093/brain/awu390

  • Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, et al. (2015) Disruption of adaptor protein 2µ (AP-2µ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing. EMBO J. doi:10.15252/embj.201591885

  • Wolf F, Engelken R, Puelma-Touzel M, Weidinger JDF, Neef A (2014) Dynamical models of cortical circuits. Current Opinion in Neurobiology.25: 228?236. doi:10.1016/j.conb.2014.01.017

  • Agudelo-Toro A, Neef A (2013) Computationally efficient simulation of electrical activity at cell membranes interacting with self-generated and externally imposed electric fields. J Neural Eng.10: 026019. doi:10.1088/1741-2560/10/2/026019