Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Löwel, Siegrid, Prof. Dr.

Professor of Systems Neuroscience

  • Professor of Systems Neuroscience, Bernstein Focus Neurotechnology (BFNT) and Johann-Friedrich-Blumenbach Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, since 2010
  • Professor of Neurobiology, Friedrich-Schiller-Universität Jena, 2005-2010
  • Scholarship in the Hertie-Excellency Program "Neurosciences"(www.ghst.de), 2004-2005
  • Dorothea-Erxleben-Guest Professorship, Otto-von-Guericke-Universität Magdeburg (http://www.unimagdeburg.de/gleichstellungsbuero/gleich/erxleb.htm), 2003-2004
  • Associate Research Physiologist/Research Associate Professor, School of Medicine, Dept. Physiology, University of California in San Francisco, U.S.A., 2002-2003
  • Head of the Research Group "Visual Development and Plasticity", Leibniz-Institut für Neurobiologie, Magdeburg, 1997-2002 & 2004-2005
  • Research Assistant, Dept. Neurophysiology (Head: Prof. Dr. Wolf Singer), Max-Planck-Institut für Hirnforschung, Frankfurt am Main, 1990-1997
  • Dr. phil. nat. (Ph.D.), 1988, Johann-Wolfgang-Goethe-Universität Frankfurt am Main

Major Research Interests

The Löwel lab is focussed on understanding the development and plasticity of neuronal circuits in the mammalian cortex. We use a combination of techniques, including optical imaging, 2-photon imaging, electrophysiology and virus-mediated knock-down to explore how experience and learning influence the structure and function of nerve cell networks. We hope that answering these key questions not only helps to understand the rules underlying brain development, functioning and learning but additionally will open up new avenues to develop clinically relevant concepts to promote regeneration and rehabilitation for diseased and injured brains. The Löwel lab has made major contributions to experience-dependent changes in nerve cell networks: We were e.g. the first to demonstrate that the learning rule for the development of long-range cortical circuits is correlated activity: "neurons wire together if they fire together" (Löwel & Singer, 1992, Science 255: 209-212).

Homepage Department/Research Group


Selected Recent Publications

  • Huang, X.*, Stodieck, S.K.*, Goetze, B., Schmidt, K.-F., Cui, L., Wenzel, C., Hosang, L., Dong, Y., Löwel, S.* and Schlüter, O.M.* (2015) The progressive maturation of silent synapses governs the duration of a critical period. Proc. Natl. Acad. Sci. of U.S.A. 112(24): E3131-40, doi: 10.1073/pnas.1506488112. Epub 2015 May 26.
  • van Wyk, M., Pielecka-Fortuna, J., Löwel, S. and Kleinlogel, S. (2015) Restoring the ON-switch in blind retinas: Opto-mGluR6, a next-generation, cell-tailored optogenetic tool. PLoS Biology 13(5):e1002143. doi: 10.1371/ journal.pbio.1002143. eCollection 2015 May.
  • Kalogeraki, E., Greifzu, F., Haack, F. and Löwel, S. (2014) Voluntary physical exercise promotes ocular dominance plasticity in adult mouse primary visual cortex. J. Neurosci 34: 15476-15481.
  • Stodieck, S. K., Greifzu, F., Goetze, B., Schmidt, K.-F. and Löwel, S. (2014) Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke. Exp. Gerontol. 60: 1-11.
  • Pielecka-Fortuna, J.*, Wagener, R.J.*, Goetze, B., Martens, A.-K., Schmidt, K.-F., Staiger, J.F.* and Löwel, S.* (2014) The disorganized visual cortex in reelin-deficient mice is highly functional and allows for enhanced plasticity. Springer Brain Struct Funct doi: 10.1007/s00429-014-0866-x
  • Greifzu, F., Pielecka-Fortuna, J., Kalogeraki, E., Krempler, K., Favaro, P D., Schlüter, O M. and Löwel, S. (2014) Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity. Proc. Natl. Acad. Sci. U.S.A. 111(3): 1150-1155.