Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences
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Friede, Tim, Prof. Dr.

Professor of Biostatistics

  • 1998 Dipl.-Math. (Master's degree in Mathematics), University of Karlsruhe, Germany

  • 2001 Dr.sc.hum. (PhD), University of Heidelberg, Germany

  • 2001-2004 PostDoc / lecturer, Dept. of Mathematics and Statistics, Lancaster University, UK

  • 2004-2006 Expert Statistical Methodologist, Novartis Pharma AG, Basel, Switzerland

  • 2006-2009 Associate Professor of Medical Statistics, University of Warwick, UK

  • since 1/2010 Professor of Biostatistics and Director, Dept. of Medical Statistics, University Medical Center Göttingen

Major Research Interests

Clinical biostatistics including designs for clinical trials (in particular flexible adaptive designs) and systematic reviews / meta-analyses.

Homepage Department/Research Group:


Selected Recent Publications

  • Varges D, Manthey H, Heinemann U, Ponto C, Schmitz M, Krasnianski A, Breithaupt M, Fincke F, Kramer K, Friede T, Zerr I (2016) Doxycycline in early CJD ? double-blinded randomized phase II and observational study. Journal of Neurology, Neurosurgery & Psychiatry (in press).

  • Nicotra A, Claus Newman C, Eremin O, Friede T, Malik O, Nicholas R (2016) Peripheral nerve dysfunction in middle-aged subjects born with thalidomide embryopathy. PLoS ONE 11(4): e0152902. doi:10.1371/journal.pone.0152902.

  • Mollenhauer B, Zimmermann J, Sixel-Döring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Trautmann E, Zetterberg H, Taylor P, Friede T, Trenkwalder C & the DeNoPa Study Group (2015) Monitoring of thirty marker candidates in early Parkinson?s disease as progression markers. Neurology 87: 168-77.

  • Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann BT, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F (2015) Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation 2016;3:e204; doi: 10.1212/NXI.0000000000000204.

  • Chataway J, Friede T (2016) The N-MOmentum trial: building momentum to advance trial methodology in a rare disease. Multiple Sclerosis Journal 22: 852?853.

  • Unkel S, Röver C, Stallard N, Benda N, Posch M, Zohar S, Friede T (2016): Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions, Orphanet Journal of Rare Diseases 11:16. http://www.ojrd.com/content/11/1/16

  • Stellmann JP, Stürner KH, Young KL, Siemonsen S, Friede T, Heesen C (2015) Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts - is there a place for baseline-to-treatment studies in MS? PLoS ONE 10(2): e0116559. doi:10.1371/journal.pone.0116559.

  • Schmidt C, Gerlach N, Peter C, Gherib K, Lange K, Friede T, Zerr I (2015) CSF Apolipoprotein E concentration and progression of Alzheimer?s Disease. Journal of Alzheimer?s Disease 43(4): 1229-1236.

  • Huppke B, Ellenberger D, Rosewich H, Friede T, Gärtner J, Huppke P (2014) Clinical presentation of pediatric multiple sclerosis before puberty. European Journal of Neurology 2: 441-446

  • Schmidt C, Wolff M, von Ahsen N, Lange K, Friede T, Zerr I (2014) CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. Journal of Clinical Neuroscience (in press)

  • Schmidt C, Becker H, Peter C, Lange K, Friede T, Zerr I (2014) Plasma prion protein concentration and progression of Alzheimer's disease. Prion (in press)

  • Schmidt C, Gerlach N, Peter C, Gherib K, Lange K, Friede T, Zerr I (2014) CSF Apolipoprotein E concentration and progression of Alzheimer's Disease. Journal of Alzheimer?s Disease (in press)

  • Mollenhauer B, Trautmann E, Sixel-Döring F, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Focke NK, Kumar K, Lohmann K, Klein C, Schlossmacher M, Kohnen R, Friede T, Trenkwalder C (2013) Non-motor and diagnostic findings in de novo Parkinson's disease subjects of the DeNoPa cohort. Neurology 81: 1226-1234

  • Steinvorth SM, Röver C, Schneider S, Nicholas R, Straube S, Friede T (2013) Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: Systematic review and meta-regression. Multiple Sclerosis Journal 19: 1580-1586

  • Nicholas R, Straube S, Schmidli H, Pfeiffer S, Friede T (2012) Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis Journal 18: 1290-1296

  • Friede T, Parsons N, Stallard N, Todd S, Valdés-Márquez E, Chataway J, Nicholas R (2011) Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis. Statistics in Medicine 30: 1528-1540

  • Chataway J, Nicholas R, Todd, S, Parsons N, Todd S, Miller D, Valdés-Márquez E, Stallard N, Friede T (2011) A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis 17: 81-88

  • Friede T, Nicholas R, Stallard N, Todd S, Parsons N, Valdés-Márquez E, Chataway J (2010) Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies With an Application to Multiple Sclerosis. Drug Information Journal 44: 713-718

  • Friede T, Schmidli H (2010) Blinded sample size reestimation with count data: Methods and applications in multiple sclerosis. Statistics in Medicine 29: 1145-1156

  • Rog DJ, Nurmikko TJ, Friede T, Young CA (2007) Validation and reliability of the neuropathic pain scale (NPS) in multiple sclerosis. Clinical Journal of Pain 23: 473–481

GGNB Friede

Prof. Dr. Tim Friede
University Medical Center Göttingen
Dept. of Medical Statistics
Humboldtallee 32
37073 Göttingen
Tel.: +49-(0)551-39 4990
Fax: +49-(0)551-39 4995
e-mail: tim.friede@med.uni-goettingen.de

GGNB Affiliation
Neurosciences (IMPRS)