Wilke, Melanie, Prof. Dr.
Professor of Cognitive Neurology
- since 2011: Schilling Foundation Professor (W3), Director of the department of Cognitive Neurology and Head of the MR-Research Unit, UKG, Georg August University Göttingen
- since 2011: Co-Investigator in the "Decision and Awareness" group (DAG) at the German Primate Center (DPZ)
- 2008-2010: Postdoctoral Fellow in the Division of Biology, Caltech, Pasadena; Advisor: Prof. R.A. Andersen
- 2005-2008: Postdoctoral Fellow in the Laboratory of Neuropsychology, NIMH, Bethesda, Advisor: Dr. D.A. Leopold
- 2001-2005: PhD student at the Max Planck Institute for Biological Cybernetics, Tübingen, Advisor: Dr. D.A. Leopold
- 1997-2001: M.A. in Psycholinguistics, Neuropsychology and Neurobiology, Ludwig-Maximilians-University, Munich, Germany
Major Research Interests
The long-term goal of our research is to understand how neural activity gives rise to spatial awareness and how distributed information is integrated to guide the selection of movement goals. Furthermore we are dedicated to perform translational research from monkey models of cognitive disorders to human patients. Current research focuses on the question how thalamic nuclei and cortical areas interact during visual perception and decision making. Another line of research is concerned with the neural mechanisms underlying spatial neglect, which is a frequent and severe consequence of brain damage in humans. Specifically, we are investigating pathological and compensatory changes in large-scale brain networks in human stroke patients by means of imaging (DTI, fMRI) and stimulation (tACS, tDCS, TMS) methods. We develop and employ monkey models of spatial neglect to study the underlying neural mechanisms by means of fMRI, electrophysiological recordings, inactivation and stimulation techniques with the goal to develop new therapeutic interventions.
Homepage Department/Research Group
Selected Recent Publications
Cabral-Calderin, Y.*, Williams, K.*, Dechent, P., Opitz, A., Wilke, M. Transcranial alternating current stimulation modulates spontaneous low frequency fluctuations as measured with fMRI. 2016. Neuroimage. 2016 Jul 5. S1053-8119(16)30312-3.
Cabral-Calderin, Y., Schmidt-Samoa, C., Wilke, M. Rhythmic gamma stimulation affects bistable perception. Journal of Cognitive Neuroscience. 2015. 20:1-10.
Tsuchiya, N., Wilke, M., Frässle, S., Lamme, V. No-report paradigms: Extracting the true neural correlates of consciousness. Trends in Cognitive Sciences. 2015. Nov 13. S1364-6613(15)00252-1.
Hwang, E., Hauschild, M., Wilke, M., Andersen, R.A. Spatial and Temporal Eye-Hand Coordination Relies on the Parietal Reach Region. Journal of Neuroscience. 2014. 34:12884-92.
Wilke, M., Kagan, I., Andersen, R.A. Effects of pulvinar inactivation on spatial decision making between equal and asymmetric reward options. Journal of Cognitive Neuroscience. 2013. 25(8), 1270-83.
Wilke, M.*, Kagan, I.*, Andersen R.A. Functional Imaging Reveals Rapid Reorganization of Cortical Activity after Parietal Inactivation in Monkeys. PNAS. 2012. 109:8274-9.
Hwang, E.J., Hauschild, M., Wilke, M., Andersen, R.A. Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades. Neuron. 2012. 76(5):1021-9.
Schmid, M.C., Mrowka, S., Turchi, J., Saunders, R., Wilke, M., Ye, F., Leopold, D.A. Blindsight functions depend on the lateral geniculate nucleus. Nature. 2010. 466(7304):373-7.
Wilke, M., Turchi, J., Smith, K., Mishkin, M., Leopold, D.A. Pulvinar inactivation disrupts selection of movement plans. Journal of Neuroscience. 2010. 30:8650-9.
Wilke, M, Mueller, K.M., Leopold, D.A. Visibility related modulation of neural responses in visual thalamic nuclei. PNAS. 2009. 106(23):9465-70.