Wirths, Oliver, Prof. Dr.*

  • 1994 - 1999 Diploma in Biology, University of Bonn, Bonn, Germany
  • 1999 - 2003 Ph.D. at University of Bonn and Catholic University Leuven
  • 2003 - 2004 Post-Doctoral fellow at Saarland University, Homburg
  • 2004 - 2006 Research Assistant at Saarland University, Homburg
  • Since 2006 Laboratory head and project leader at the Molecular Psychiatry lab, University Medical Center Göttingen
  • 2012 Habilitation (Venia legendi) in Molecular Neurosciences, University Medical Center Göttingen
  • Since 2017 Apl. Professorship, University Medical Center Göttingen

Major Research Interests

Neurobiology and biochemistry of Alzheimer's disease, transgenic mouse models of neurodegenerative diseases (neuropathology, biochemistry, expression profiling and behavioral analysis), exercise and neurodegeneration, axonal degeneration

Homepage Department/Research Group


Selected Recent Publications

  • Saul A., Wirths O. (2017) Endogenous Apolipoprotein E (ApoE) fragmentation in transgenic mouse models of Alzheimer's disease. Molecular Neurobiology, 54: 319-327
  • Hüttenrauch M., Brauß A., Kurdakova A., Borgers H., Klinker F., Liebetanz D., Salinas-Riester G., Wiltfang J., Klafki H.W., Wirths, O. (2016) Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model. Translational Psychiatry, 6:e800
  • Christensen D.Z., Huettenrauch M., Mitkovski M., Pradier L., Wirths O. (2014) Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation. Frontiers in Aging Neuroscience, 6:139
  • Wirths O., Erck C., Martens H., Harmeier A., Geumann C., Jawhar S., Kumar S., Multhaup G., Walter J., Ingelsson M., Degerman-Gunnarson M., Kalimo H., Huitinga I., Lannfelt L., Bayer T.A. (2010) Identification of low molecular weight pyroglutamate Abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. Journal of Biological Chemistry, 285(53): 41517-41524
  • Christensen D.Z., Schneider-Axmann T., Lucassen P.J., Bayer T.A., Wirths O. (2010) Intraneuronal Aβ accumulation correlates with ApoE4 genotype. Acta Neuropathologica, 119 (5): 555-566
  • Wirths O., Breyhan H., Cynis H., Schilling S., Demuth H.U., Bayer T.A. (2009) Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathologica, 118 (4): 487-496