Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Prof. Dr. Stefan Klumpp

  • 1999 Diploma in Physics, University of Heidelberg, Germany
  • 2003 Dr. rer. nat., Physics, University of Potsdam, Germany
  • 2004–2005 Research associate, MPI of Colloids and Interfaces, Potsdam, Germany
  • 2006–2009 Postdoc, University of California, San Diego, USA
  • 2009–2016 Group leader, MPI of Colloids and Interfaces, Potsdam, Germany
  • since 2015 Professor of Theoretical Biophysics, Georg August University, Göttingen, Germany

Major Research Interests

    Biological processes must obey the laws of physics, but are also subject to functional requirements and shaped by the forces of evolution. Our group is interested in how functional requirements are implemented within the given physical constraints. To that end, we develop theoretical tools to describe complex regulatory systems and their coupling to the cellular context. Topics of specific interest are
    - molecular machines (cytoskeletal motors, RNA polymerases, ribosomes),
    - gene circuits and cell growth,
    - (bacterial) cell motility.

Homepage Department/Research Group

Selected Recent Publications

  • V. Bierbaum and S. Klumpp (2015) Impact of the cell division cycle on gene circuits. Phys. Biol. 12, 066003
  • S. Klumpp C. Keller, F. Berger and R. Lipowsky (2015) Cooperative phenomena of multiple molecular motors, in: Multiscale Modeling in Biomechanics and Mechanobiology. edited by S. De, W. Hwang, E. Kuhl (Springer, London) pp. 27-61
  • M. Mauri and S. Klumpp (2014) A model for sigma factor competition in bacterial cells, PLoS Comp. Biol. 10, e1003845
  • C.T. Lefèvre, M. Bennet, L. Landau, P. Vach, D. Pignol, D.A. Bazylinski, R.B. Frankel, S. Klumpp and D. Faivre (2014) Diversity of magneto-aerotactic behaviors and oxygen sensing mechanisms in cultured magnetotactic bacteria, Biophys. J. 107, 527-538
  • R. Marathe, C. Meel, N.C. Schmidt, L. Dewenter, R. Kurre, L. Greune, M.A. Schmidt, M.J.I. Müller, R. Lipowsky, B. Maier and S. Klumpp (2014) Bacterial twitching motility is coordinated by a two-dimensional tug-of-war with directional memory, Nature Commun. 5, 3759
  • S. Klumpp, M. Scott, S. Pedersen and T. Hwa (2013) Molecular crowding limits translation and cell growth, Proc. Natl. Acad. Sci. USA 110, 16754-16759