Braus, Gerhard, Prof. Dr.
Professor of Microbiology and Genetics
- 1983 Diploma (Biology), Albert-Ludwig University, Freiburg i. Br. (Germany)
- 1987 Dr.sc.nat., Swiss Federal Institute of Technology (ETH), Zürich (Switzerland)
- 1991 Habilitation (Microbiology), Swiss Federal Institute of Technology (ETH), Zürich (Switzerland)
- 1993 - 1996 Associate Professor of Biochemistry, Friedrich Alexander University, Erlangen (Germany)
- Since 1996 Professor of Microbiology (since 2001 Professor of Microbiology and Genetics) in Göttingen
Major Research Interests
The major focus of the laboratory is on the control of developmental programs, protein turnover, pathogenicity and the interplay between development and primary and secondary metabolism. Our models are eukaryotic microorganisms (yeasts and filamentous fungi):
(i) We are interested how light coordinates fungal development with fungal secondary metabolism and toxin production.
(ii) Nedd8 is a ubiquitin-like protein which is involved in the control of protein turnover. We study the Nedd8-system including the COP9 signalosome using fungi as model systems.
(iii) We are interested in the molecular control (protein turnover and translation) of adhesion as initial step in infection and biofilm formation.
(iv) We study fungi as models for Parkinson (yeast), fungi as pathogens of immunocompromised patients (A. fumigatus) and as plant pathogens (V. longisporum).
Homepage Department/Research Group
Selected Recent Publications
- Sarikaya-Bayram Ö, Bayram Ö, Feussner L, Kim JH, Kim HS, Kaever A, Feussner I, Chae KS, Han DM, Han KH, Braus GH (2014) The membrane-bound VapA-VipC-VapB methyltransferase complex guides signal transduction for epigenetic and transcriptional control of fungal development. Dev. Cell 29, 1-15. [Journal Cover].
- Ahmed YL, Gerke J, Park HS, Bayram Ö, Neumann P, Ni M, Dickmanns A, Kim SC, Hyuk JH Yu#, Braus GH#, Ficner R# (2013) Fungal velvet regulators contain a DNA binding domain reminiscent of NF-?B. PLoS Biol. 11: e1001750 (# corresponding authors). [Synopsis to the paper in: PLoS Biol. 11, e1001751].
- Christmann M, Schmaler T, Gordon C, Huang X, Bayram Ö, Schinke J, Stumpf S, Dubiel W, Braus GH (2013). Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome (2013) PLoS Genet. 9: e1003275.
- Rachfall N, Bandau S, Ehrenreich A, Valerius O, Braus GH (2013) RACK1/Asc1p, a ribosomal node in cellular signalling. Mol. Cell. Proteomics. 12: 87-105.
- Bayram Ö, Sarikaya Bayram Ö., Ahmed YL, Maruyama J, Valerius O, Rizzoli SO, Ficner R, Irniger S, Braus GH (2012) The A. nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism. PLoS Genet. 8: e1002816 [Journal Cover].
- Sarikaya ÖB, Bayram Ö, Valerius O, Park HS, Irniger S, Gerke J, Ni M, Han KH, Yu JH, Braus GH (2010) LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet. 6: e1001226 [Journal Cover].
- Bayram Ö, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science. 320: 1504-1506. [Comment to the paper in Perspectives: Science 320: 1430-1431].