Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences
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Brose, Nils, Prof. Dr.

Professor, Director at the Max Planck Institute for Experimental Medicine

  • Undergraduate studies in Biochemistry, Eberhard Karls University, Tübingen, Germany (1981-1985)

  • MSc in Physiology with Marianne Fillenz, University of Oxford, Oxford, UK (1987)

  • PhD in Biology with Reinhard Jahn, Ludwig Maximilians University, Munich, Germany (1990)

  • Postdoctoral training with Stephen F. Heinemann (Salk Institute, La Jolla, CA, USA) and Thomas C. Südhof (University of Texas Southwestern Medical Center, Dallas, TX, USA) (1991-1995)

  • Research Group Leader, Max Planck Institute of Experimental Medicine, Göttingen, Germany (1995-2001)

  • Director, Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany (since 2001)

Major Research Interests

Research in the Department of Molecular Neurobiology focuses on the molecular mechanisms of nerve cell development and synapse formation and function in the vertebrate central nervous system. We combine biochemical, morphological, mouse genetic, behavioral, and physiological methods to elucidate the molecular basis of nerve cell differentiation, synapse formation, transmitter release processes, and postsynaptic transmitter sensing. Our work in the field of nerve cell development focuses on the role of protein ubiqutination and SUMOylation in cell polarity formation, cell migration, and neuritogenesis. The synaptogenesis research in our group concentrates on synaptic cell adhesion proteins, their role in synapse formation and function, and their dysfunction in neuropsychiatric diseases. Studies on the molecular mechanisms of neurotransmitter release focus on components of the presynaptic active zone and their regulatory function in synaptic vesicle fusion.

Homepage Department/Research Group


Selected Recent Publications

  • Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee J-S, Brose N (2015) Perturbed hippocampal synaptic inhibition and gamma-oscillations in a Neuroligin-4 knock-out mouse model of autism. Cell Rep. 13: 516-523

  • Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N (2014). A conformational switch in Collybistin determines the differentiation of inhibitory postsynapses. EMBO J 18: 2113-2133

  • Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, Südhof TC, Rhee J, Brose N*, Cooper BH* (2014). The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron 84: 416-431 (*joint corresponding authors)

  • Lipstein N, Sakaba T, Cooper BH, Lin K-H, Strenzke N, Ashery U, Rhee J-S, Taschenberger H, Neher E, Brose N (2013) Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca2+-Calmodulin-Munc13-1 signaling. Neuron 79: 82-96

  • Tirard M, Hsiao H-H, Nikolov M, Urlaub H, Melchior F, Brose N (2012) In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. Proc Natl Acad Sci USA 109: 21122-21127

  • Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J-S, Kirchhoff F, Brose N (2011) In vivo imaging of inter-synaptic vesicle exchange using VGLUT1Venus knock-in mice. J Neurosci 31, 15544-15559.

  • Kawabe H, Neeb A, Dimova K, Young SM Jr, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang D-E, Umikawa M, Kariya K, Goebbels S, Nave K-A, Rosenmund C, Jahn O, Rhee J-S, Brose N (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development in cortical neurons. Neuron 65, 358-372.

  • Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N (2008) Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci USA 105, 1710-1715.

  • Jockusch W, Speidel D, Sigler A, S°rensen J, Varoqueaux F, Rhee J-S, Brose N (2007) CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131, 796-808.

GGNB Brose

Prof. Dr. Nils Brose
Max Planck Institute
for Experimental Medicine
Dept. of Molecular Neurobiology
Hermann-Rein-Str. 3
37075 Göttingen

Tel.: +49-(0)551-38 99725
Fax: +49-(0)551-38 99715
e-mail: brose@em.mpg.de

GGNB Affiliation
Molecular Biology (IMPRS)
Neurosciences (IMPRS)
Biomolecules: Structure - Function -
Dynamics (GZMB)

Genes and Development
Molecular Physiology of the Brain (C

Systems Neuroscience
Sensory and Motor Neuroscience