Moser, Tobias, Prof. Dr.
Professor of Auditory Neuroscience
- M.D. University of Jena, 1995
- Postdoc with E. Neher at the MPI for Biophysical Chemistry, 1994 - 1997
- Junior Group Leader at the at the MPI for Biophysical Chemistry, Göttingen, 1997-2001
- Leader of the InnerEarLab and Clinical Work at the Department of Otolaryngology, University Medical Center Göttingen since 2001
- Director of the Institute for Auditory Neuroscience, University Medical Center Göttingen and group leader at the MPIs for Experimental Medicine and Biophysical Chemistry and the German Primate Center
Major Research Interests
Auditory Neuroscience - Synaptic Physiology and Pathophysiology - Audiology and Neuroprosthetics
Our work focuses on the molecular anatomy, physiology and pathophysiology of sound encoding and information processing in the auditory system as well as the restoration of hearing by gene replacement therapy and optogenetic stimulation. We combine various techniques to characterize synapses of hair cells and the auditory brainstem from the molecular to the systems level. This way we have contributed to the understanding of structure and function of auditory synapses and initiated the concept of auditory synaptopathy. Towards restoration of hearing we aim to establish virus-mediated gene replacement therapy of auditory synaptopathy and pursue the optogenetic stimulation of auditory nerve for improving the performance of the cochlear implant.
Homepage Department/Research Group
Selected Recent Publications
- Picher MM, Gehrt A, Meese S, Ivanovic A, Predoehl F, Jung SY. Schrauwen I, Dragonettik AG, Colombo R, Van Camp V, Strenzke N, Moser T (2017) Ca2+-binding protein 2 inhibits Ca2+ channel inactivation in mouse inner hair cells. PNAS, 114: E1717-E1726
- Ohn TZ, Rutherford MA, Jing Z, Jung SY, Duque-Afonso CJ, Hoch G, Picher MM, Scharinger A, Strenzke N, Moser T (2016) Hair cells employ active zones with different voltage-dependence of Ca2+-influx to decompose sounds into complementary neural codes. PNAS, 113(32):E4716-25.
- Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T (2015) Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing. EMBO J 34(21): 2686-702
- Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz, L, Strenzke N, Moser T (2014) Optogenetic stimulation of the auditory pathway. J Clin Investigation, 124(3): 1114-29
- Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, and Moser T (2014) Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis. EMBO J, 33,247-64
- Chapochnikov, NM, Takago,, H, Huang, CH, Pangrsic, T, Khimich, D, Neef, J, Auge, E, Göttfert, F, Hell, SW, Wichmann, C#, Wolf F#, Moser T# (2014) Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis. Neuron 83: 1-15