Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences
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Moser, Tobias, Prof. Dr.


Professor of Auditory Neuroscience


  • M.D. University of Jena, 1995

  • Postdoc with E. Neher at the MPI for Biophysical Chemistry, 1994 - 1997

  • Junior Group Leader at the at the MPI for Biophysical Chemistry, Göttingen, 1997-2001

  • Leader of the InnerEarLab and Clinical Work at the Department of Otolaryngology, University Medical Center Göttingen since 2001

  • Director of the Institute for Auditory Neuroscience, University Medical Center Göttingen and group leader at the MPIs for Experimental Medicine and Biophysical Chemistry and the German Primate Center



Major Research Interests

Auditory Neuroscience - Synaptic Physiology and Pathophysiology - Audiology and Neuroprosthetics

Our work focuses on the molecular anatomy, physiology and pathophysiology of sound encoding and information processing in the auditory system as well as the restoration of hearing by gene replacement therapy and optogenetic stimulation. We combine various techniques to characterize synapses of hair cells and the auditory brainstem from the molecular to the systems level. This way we have contributed to the understanding of structure and function of auditory synapses and initiated the concept of auditory synaptopathy. Towards restoration of hearing we aim to establish virus-mediated gene replacement therapy of auditory synaptopathy and pursue the optogenetic stimulation of auditory nerve for improving the performance of the cochlear implant.


Homepage Department/Research Group

http://www.auditory-neuroscience.uni-goettingen.de/

http://www.innerearlab.uni-goettingen.de/

https://www.mpibpc.mpg.de/14722384/moser

http://www.dpz.eu/en/platforms/optogenetics/auditory-neuroscience.html


Selected Recent Publications


  • Frank T, Rutherford MA, Strenzke N, Pangrsic T, Khimich D, Fejtova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T (2010). Bassoon and the synaptic ribbon organize Ca2+ channels and vesicles to add release sites and promote refilling. Neuron 68, 724-738

  • Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Müller U, Brose N, Reisinger E*, Moser T* (2010) Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci 13(7), 869-76

  • Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz, L, Strenzke N, Moser T (2014) Optogenetic stimulation of the auditory pathway. J Clin Investigation, 124(3): 1114-29

  • Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, and Moser T (2014) Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis. EMBO J, 33,247-64

  • Chapochnikov, NM, Takago,, H, Huang, CH, Pangrsic, T, Khimich, D, Neef, J, Auge, E, Göttfert, F, Hell, SW, Wichmann, C#, Wolf F#, Moser T# (2014) Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis. Neuron 83: 1-15







GGNB Moser

Adresse
Prof. Dr. Tobias Moser
Universitätsmedizin Göttingen
Institut für Auditorische Neurowissenschaften & InnenOhrLabor
Robert-Koch-Str. 40
37075 Göttingen

Tel.: +49-(0)551-3922803
Fax: +49-(0)551-3922299
e-mail: tmoser@gwdg.de

GGNB-Zugehörigkeit
Neurosciences (IMPRS)
Molecular Biology (IMPRS)
Molecular Physiology of the Brain (C
MPB)

Sensory and Motor Neuroscience
Systems Neuroscience
Theoretical and Computational Neur
oscience