Schlüter, Oliver, Dr. Dr.
- M.D. Ph.D. with Thomas C. Südhof at the Max-Planck-Institute for Experimental Medicine in Göttingen (Germany), 1995 - 2001
- Dr. rer. nat. (PhD) 2000, University of Hannover
- Dr. med. (Medical thesis) 2001, University of Göttingen
- Postdoc with Christian Rosenmund and Reinhard Jahn at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, 2001-2002
- Postdoc with Robert C. Malenka at Stanford University Medical Center (USA), 2002 - 2006
- Independent group leader (Emmy-Noether/DFG) at the European Neuroscience Institute Göttingen (ENI-G), 2006 - 2015
- Assistant Professor at the Department of Neuroscience, University of Pittsburgh, since 2015
- Adjunct Professor at the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, since 2016
Major Research Interests
Activity-dependent modulations of synaptic transmission are important mechanisms of information processing and storage in neuronal circuits. A variety of related but mechanistically distinct forms of synaptic plasticity have been described in in vitro preparations of brain slices.
A major goal of my laboratory is to elucidate the underlying molecular events, leading to and regulating changes in synaptic efficacy. Newly developed techniques of molecular replacement, using mouse genetics and/or viral-mediated gene transfer allow us to manipulate the molecular composition of single neurons in a spatial and temporal controlled manner.
In particular, we are able to investigate the effects of heterologously expressed proteins on the background of wild-type neurons, or neurons, in which the endogenous protein expression is diminished. We combine this technique with simultaneous dual whole cell patch clamp recordings from rodent brain slices to monitor changes in synaptic efficacy in the manipulated cell in comparison to the neighboring control cell.
Knowledge gained from the understanding of molecular mechanisms of synaptic transmission and plasticity will ultimately provide important clues for the function of neuronal ircuits and potentially the functioning of the brain.
Homepage Department/Research Group
Selected Recent Publications
- Liu Y, Cui L, Schwarz MK, Dong Y, Schlüter OM (2017) Adrenergic Gate Release for Spike Timing-dependent Synaptic Potentiation. Neuron 93(2):394-408.
- Shukla A, Beroun A, Panopoulou M, Neumann PA, Grant SGN, Olive MF, Dong Y, Schlüter OM (2017) Calcium-permeable AMPA Receptors and Silent Synapses in Cocaine-conditioned Place Preference. EMBO J 36(4):458-74.
- Huang X*, Stodieck SK*, Goetze B, Cui L, Wong MH, Wenzel C, Hosang L, Dong Y, Löwel S#, Schlüter OM# (2015). Progressive Maturation of Silent Synapses Governs the Duration of a Critical Period. PNAS. 112(24): E3131-40.
- Lee BR*, Ma Y*, Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y# (2013). Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci 16(11): 1644-51.
- Krüger JM, Favaro PD, Liu M, Kitlinska A, Huang X, Raabe M, Akad DS, Liu Y, Urlaub H, Dong Y, Xu W, Schlüter OM# (2013). Differential roles of Postsynaptic Density-93 isoforms in regulating synaptic transmission. J Neurosci 33(39): 15504-17.
- Bonnet SA*, Akad DS*, Samaddar T, Liu Y, Huang X, Dong Y, Schlüter OM# (2013). Synaptic state-dependent functional interplay between Postsynaptic Density-95 and Synapse-associated Protein 102. J Neurosci 33(33):13398-409.
- Brown TE, Lee BR, Mu P, Ferguson D, Dietz D, Ohnishi YN, Lin Y, Suska A, Ishikawa M, Huang YH, Shen H, Kalivas PW, Sorg BA, Zukin RS, Nestler EJ, Dong Y#, Schlüter OM# (2011). A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci 31(22):8163-74.