Wouters, Fred S., Prof. Dr.

Professor, Laboratory for Molecular and Cellular Systems

1997: Dr. (Ph.D.), Faculty of Chemistry, University of Utrecht, The Netherlands
1997-2000: Postdoctoral fellow, Imperial Cancer Research Fund (ICRF), London UK
2000-2001: Postdoctoral fellow, European Molecular Biology Laboratory (EMBL), Heidelberg
2001: Appointed as group leader at the European Neuroscience Institute Göttingen
2006: PD (habilitation), Physiology, University of Göttingen
since July 2007: Professor

Major Research Interests
Our research focusses on the working and regulating of cellular molecular machines in health and disease. Examples include tyrosine kinase receptor signalling, programmed non-apoptotic cell death signalling and the mechanisms involved in inhibitory synapse formation. Mechanistic insight is obtained by the use of advanced quantitative fluorescence microscopy techniques. These primarily include Fluorescence Lifetime Imaging Microscopy (FLIM), and Förster Resonance Energy Transfer (FRET) microscopy. Furthermore, we design targeted optical assays for specific biological functions and activities with a focus on multiplexed detection in order to discover and/or describe connections and causalities.
In close collaboration with the UMG technology platform for Clinical Optical Microscopy (CLINOMIC) of Dr. Bunt, we recently started the development of volumetric deep tissue imaging techniques for use with human pathological tissue. Recent advances include a fast and effective method for optical clearing of large volumes of formaldehyde fixed pathological tissue and the development of a light sheet fluorescence microscope for cm-sized samples with 3-dimensional cellular resolution. With the implementation of advanced imaging techniques in pathology, we aim to introduce new and improved optical tools for clinical diagnosis.

Homepage Department/Research Group
https://neuropathologie.umg.eu/forschung/arbeitsgruppen-labore/ag-woutersbunt/