Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences
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Antal, Andrea, Prof. Dr.


Group Leader Clinical Neurophysiology


  • 1990 - Diploma in Biology, Attila József University of Sciences, Szeged, Hungary

  • 1993 - University Doctor, Attila József University of Sciences, Szeged, Hungary

  • 1998 - Albert Szent-Györgyi Medical University, Szeged, Hungary

  • 2005 Habilitation Georg-August University, Göttingen, Germany

  • 2010 Extraordinary professor, Georg-August University, Göttingen, Germany



Major Research Interests

Neuroplasticity became one central topic of neuroscience research in the last decades. Dynamic modifications of neuronal networks are an important substrate for learning and memory formation. Furthermore, pathological neuroplasticity might be one foundation of numerous central nervous system diseases.

The primary aim of our recent work is to develop and establish new non-invasive brain stimulation methods to induce physiological changes in the central nervous system in order to investigate cognition and complex information processing. Transcranial direct current stimulation (tDCS) was developed by our group as a non-invasive tool to induce neuroplasticity in the human cerebral cortex. tDCS as a tool aims to induce prolonged neuronal excitability and activity alterations in the human brain via alterations of the neuronal membrane potential. Accordingly, this method is a promising tool in the treatment of diseases that are accompanied by changes of cortical excitability. Transcranial alternating current stimulation (tACS) and random noise stimulation (tRNS) are new external stimulation techniques influencing cortical activity. tACS and tRNS permit, due to the oscillating stimulation, external interference with the cortical oscillations. They can particularly modulate the temporary connections of cortical areas during a given task. Neuronal oscillations in the brain are associated with the processing of sensory information, learning, cognition, arousal, attention and also pathological conditions (e.g. Parkinson's tremor, epilepsy). Therefore, the external modulation of cortical oscillations could be an important component of induced cerebral plasticity. In terms of effectiveness tRNS seems to have at least the same therapeutic potential for the treatment of diseases such as depression and chronic pain as rTMS and tDCS.



Homepage Department/Research Group

http://www.neurologie.uni-goettingen.de/



Selected Recent Publications


  • Alekseichuk I, Turi Z, de Lara G, Antal A, Paulus W. Spatial working memory in humans depends on theta and high gamma synchronization in prefrontal cortex. Current Biology, 2016, 26:1513-21.

  • Antal A, Herrmann CS. Transcranial alternating current and random noise stimulation: Possible mechanisms. Neural Plasticity, 2016: 3616807.

  • Antal A. On the way to understanding migraine. Editorial: Coppola et al.: Lateral inhibition in the somatosensory cortex during and between migraine without aura attacks: correlations with thalamocortical activity and clinical features, Cephalalgia, 2016, 36:725-6.

  • Alekseichuk I, Diers K, Paulus W, Antal A. Transcranial electrical stimulation of the occipital cortex during visual perception modifies the magnitude of BOLD activity: a combined tES-fMRI approach. Neuroimage, 2015, pii: S1053-8119(15)01056-3.

  • Ambrus GG, Pisoni A, Primaßin A, Turi Z, Paulus W, Antal A. Bi-frontal transcranial alternating current stimulation in the ripple range reduced overnight forgetting. Frontiers in Cellular Neuroscience, 2015, 9:374.

  • Pisoni A, Turi Z, Raithel A, Ambrus GG, Alekseichuk I, Schacht A, Paulus W, Antal A. Separating recognition processes of declarative memory via anodal tDCS: boosting old item recognition by temporal and new item detection by parietal stimulation. PlosOne, 2015; 10(3):e0123085.

  • Turi Zs, Mittner M, Opitz A, Popkes M, Paulus W, Antal A. Transcranial direct current stimulation over the left prefrontal cortex increases randomness of choice in instrumental learning. Cortex, 2015; 63C:145-154.

  • Moliadze V, Antal A, Paulus W. Boosting brain excitability by transcranial high frequency stimulation in the ripple range. Journal of Physiology, 2010, 588:4891-904.

  • Antal A, Bikson M, Datta A, Lafon B, Dechent P, Parra LC, Paulus W. Imaging artifacts induced by electrical stimulation during conventional fMRI of the brain. NeuroImage, 2014; 85:1040?1047

  • Terney D, Chaieb L, Moliadze V, Antal A, Paulus W. Increasing human brain excitability by transcranial high frequency random noise stimulation. Journal of Neuroscience, 2008; 28:14147-55.








GGNB_Antal

Address

Prof. Dr. Andrea Antal
Göttingen University Medical School
Dept. of Clinical Neurophysiology
Robert-Koch-Straße 40
37075 Göttingen
Germany

Tel.: +49-551-39 8461
Fax: +49-551-39 8126
e-mail: AAntal@gwdg.de

GGNB Affiliation
Sensory and Motor Neuroscience
Systems Neuroscience
Neurosciences (IMPRS)