Veranstaltung
Dynamic Nuclear Polarization – Boosting the Sensitivity of liquid state Nuclear Magnetic Resonance| Titel der Veranstaltung | Dynamic Nuclear Polarization – Boosting the Sensitivity of liquid state Nuclear Magnetic Resonance |
| Reihe | campus seminar |
| Veranstalter | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Referent/in | Marcel Levien |
| Einrichtung Referent/in | Electron Paramagnetic Resonance Group |
| Veranstaltungsart | Seminar |
| Kategorie | Forschung |
| Anmeldung erforderlich | Nein |
| Beschreibung | Throughout the past decades, Nuclear Magnetic Resonance (NMR) has been used to investigate increasingly challenging and complex systems. As of today, the applications of NMR range from small organic molecules over proteins to material sciences. Its particular strength lies within the unique capability to grasp the structure as well as the dynamic behaviour of such complex systems. However, NMR suffers from an intrinsic low sensitivity, which stems from the low nuclear Zeeman energy compared to the thermal energy. In the beginning of NMR, this problem was tackled by increasing the magnetic field, developing new pulse sequences and improving hardware and detection schemes. Yet, as of today, measurement times can still exceed days and weeks, and certain experiments for less sensitive nuclei may be unfeasible. A different way to alleviate the sensitivity issue is Dynamic Nuclear Polarization (DNP), a method, where spin polarization is transferred via microwave irradiation from highly polarized electron spins to nuclear spins. With the advent of gyrotrons, which is a high power and high frequency microwave source, DNP became commercially available for applications in solid-state NMR. In liquids at room temperature, DNP is still in the developmental phase. Its viability at high magnetic field has only recently been demonstrated [1]. Large signal enhancements for 13C nuclei at high magnetic field were reported for several model compounds [2] as well as more moderate enhancements for biological compounds such as amino acids [3]. In this talk, the general principles of NMR and DNP in liquids will be discussed. In the end, the current developments of liquid state DNP and their potential for applications in NMR will be presented. [1] G. Liu, M. Levien, N. Karschin, G. Parigi, C. Luchinat, M. Bennati, Nat. Chem. 2017, 9, 676. [2] T. Orlando, R. Dervisoglu, M. Levien, I. Tkach, T. F. Prisner, L. Andreas, V. Denysenkov, M. Bennati, Angew. Int. Ed. 2019, 58, 1402. [3] D. Dai, X. Wang, Y. Liu, X.-L. Yang, C. Glaubitz, V. Denysenkov, X. He, T. F. Prisner, J. Mao, Nat. Commun. 2021, 12, 6880. |
| Zeit | Beginn: 02.03.2022, 11:00 Uhr Ende: 02.03.2022 , 12:00 Uhr |
| Ort |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Online |
| Kontakt |
Stefan Glöggler stefan.gloeggler@mpibpc.mpg.de |