Veranstaltung

Cytoplasmic streaming in C.elegans : a self-organized flow driven at the cell surface

Titel der Veranstaltung	Cytoplasmic streaming in C.elegans : a self-organized flow driven at the cell surface
Reihe	LMP Seminar
Veranstalter	Physik lebender Materie
Referent/in	Dr. Alexandre Gabriel Mamane
Einrichtung Referent/in	Dept. of Fluid Physics, Pattern Formation, and Biocomplexity, MPI for Dynamics and Self-Organization
Veranstaltungsart	Seminar
Kategorie	Forschung
Anmeldung erforderlich	Nein
Beschreibung	Cytoplasmic streaming is a type of collective movement of cytoplasm observed in many cell types. The mechanism of meiotic cytoplasmic streaming (MeiCS) in Caenorhabditis elegans zygotes is puzzling as the direction of the flow is not predefined by cell polarity and occasionally reverses. We develop a theoretical model, which reproduces and predicts the emergence and reversal of the flow. We propose a positive-feedback mechanism, where the local flow generated along a microtubule aligns the neighboring filaments by the mean of hydrodynamics interactions through endoplasmic reticulum (ER). We find that the flow is close to the critical state in the phase transition diagram, which suggests that fluctuations play a bigger role in this system than the mean flow. A biological function is proposed: the mobility of cortical granules is increased by MeiCS and improves the efficiency of the exocytosis of the granules to protect the zygotes. Also, the sperm-derived pronucleus/centrosome complex is drifted randomly to determine the cell polarity. The active diffusion induced by this system and the flow pattern in relation with the surface geometry remain to be understood.
Zeit	Beginn: 16.11.2021, 14:00 Uhr Ende: 16.11.2021 , 15:30 Uhr
Ort	Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS) (Am Faßberg 17) Video conference at www.zoom.us Meeting ID: 997 1155 2453 Passcode: 771001
Kontakt	Prof. Dr. Ramin Golestanian golestanian-office@ds.mpg.de