Sensory Research in Göttingen

Strenzke, Nicola, MD

Junior Group leader at the Department of Otolaryngology

- Dr. med. (M.D.), 2003, University of Lübeck
- Clinical work and postdoctoral research in the Department of Otolaryngology, University of Göttingen, since 2003
- Postdoctoral fellowship with M.C. Liberman at the Eaton-Peabody Laboratory/Massachussetts Eye and Ear infirmary/Harvard medical school, Boston, 2006-2007
- Junior Group leader “Auditory Systems Physiology” at the Department of Otolaryngology, University of Göttingen, since 2007

Major Research Interests

The group follows a system physiology approach to characterize mechanisms and functional consequences of sensorineural hearing loss. Various gross and fine electrophysiological in vivo recording techniques from the cochlea, auditory nerve and brainstem, and morphological studies are employed to gain insight into sound encoding in the rodent auditory system under normal and diseased conditions. The correlation of our results with in vitro studies and clinical findings aims to improve our understanding of auditory physiology and of diagnostic and therapeutic strategies in hearing-impaired subjects.

Homepage Department/Research Group:

Selected publications

- Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T (2010): Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci. 13:869-76.

- Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC (2010): Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. J Neurosci 30:7587-97.

- Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina A, Neef A, Brose N, Xu-Friedman M, Moser T (2009): A positive role of complexin I for high fidelity transmission at the endbulb of Held auditory synapse. J Neurosci 29:7991-8004.

- Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N*, Moser T* (2009).The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing. J Neurosci 29:10730-40. *shared correspondent authorship

- Rickheit G, Maier H, Strenzke N, Andreescu CE, De Zeeuw CI, Muenscher A, Zdebik AA, Jentsch TJ (2008): Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV. EMBO J 27: 2907–2917