Strenzke, Nicola, Dr. med.*

Junior Group leader, Otorhinolaryngology & InnerEarLab

  • Dr. med. (M.D.), 2003, University of Lübeck
  • Clinical assistant and postdoctoral fellow in the Department of Otolaryngology, University of Göttingen, since 2003
  • Postdoctoral research fellowship with M.C. Liberman at the Eaton-Peabody Laboratory/Harvard medical school, Boston, 2006-2007
  • Junior Group leader “Auditory Systems Physiology” at the Department of Otolaryngology, University of Göttingen, since 2007

Homepage Department/Research Group

Major Research Interests

The group follows a system physiology approach to characterize mechanisms and functional consequences of sensorineural hearing loss. Various gross and fine electrophysiological in vivo recording techniques from the cochlea, auditory nerve and brainstem, and morphological studies are employed to gain insight into sound encoding in the rodent auditory system under normal and diseased conditions. The correlation of our results with in vitro studies and clinical findings aims to improve our understanding of auditory physiology and of diagnostic and therapeutic strategies in hearing-impaired subjects.

Selected publications

  • Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina A, Neef A, Brose N, Xu-Friedman M, Moser T (2009): A positive role of complexin I for high fidelity transmission at the endbulb of Held auditory synapse. J Neurosc 29: 7991-8004
  • Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N*, Moser T* (2009).The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing. J Neurosci 29:10730-40. *shared correspondant authorship
  • Rickheit G, Maier H, Strenzke N, Andreescu CE, De Zeeuw CI, Muenscher A, Zdebik AA, Jentsch TJ (2008): Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV. EMBO J. 27:2907-17
  • Pauli-Magnus D, Hoch G, Strenzke N, Anderson S, Jentsch TJ, Moser T (2007): Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses. Neuroscience 149: 673-84
  • Schmitz, F, Tabares, L, Khimich, D, de la Villa-Polo, P, Strenzke, N, Castellano-Muñoz, M, Moser, T, Fernández-Chacón, R, Südhof, TC (2006): CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. PNAS 103 (8) 2926-2931